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1. (WO2010077671) STABLE PERFLUOROCARBON EMULSION FOR USE AS AN ARTIFICIAL OXYGEN CARRIER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077671 International Application No.: PCT/US2009/067179
Publication Date: 08.07.2010 International Filing Date: 08.12.2009
IPC:
A61K 9/107 (2006.01) ,A61K 47/30 (2006.01) ,A61K 9/10 (2006.01) ,A61K 31/35 (2006.01) ,A61K 31/56 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
Applicants:
UNIVERSITY OF UTAH RESEARCH FOUNDATION [US/US]; 615 Arapeen Drive, Suite 310 Salt Lake City, UT 84108, US (AllExceptUS)
RAPOPORT, Natalya, Y. [US/US]; US (UsOnly)
PRESTWICH, Glenn, D. [US/US]; US (UsOnly)
CONDIE, Russell, Morris [US/US]; US (UsOnly)
Inventors:
RAPOPORT, Natalya, Y.; US
PRESTWICH, Glenn, D.; US
CONDIE, Russell, Morris; US
Agent:
ERICKSEN, Erik, S.; Thorpe North & Western, Llp Po Box 1219 Sandy, UT 84091-1219, US
Priority Data:
61/201,26108.12.2008US
Title (EN) STABLE PERFLUOROCARBON EMULSION FOR USE AS AN ARTIFICIAL OXYGEN CARRIER
(FR) ÉMULSION DE PERFLUOROCARBONE STABLE POUR UNE UTILISATION EN TANT QUE SUPPORT D'OXYGÈNE ARTIFICIEL
Abstract:
(EN) Perfluorocarbon emulsions having a high stability and good oxygen release are disclosed and described. These perfluorocarbon emulsions are typically for use as artificial oxygen carriers. The perfluorocarbon emulsions include a disperse phase of a perfluorocarbon and an emulsion stabilizer, and continuous phase. The emulsion stabilizer can primarily include a poly(ethylene oxide) block copolymer. These stabilized perfluorocarbon emulsions can be used in liquid and/or hydrogel phases of perfusion bioreactors or various other culture systems to enhance cell viability in thick tissue constructs, or as blood substitutes, although other applications may also be considered.
(FR) La présente invention porte sur des émulsions de perfluorocarbone présentant une stabilité élevée et une bonne libération d'oxygène. Ces émulsions de perfluorocarbone sont typiquement destinées à être utilisées en tant que support d'oxygène artificiel. Les émulsions de perfluorocarbone comprennent une phase dispersée composée d'un perfluorocarbone et d'un stabilisateur d'émulsion, et une phase continue. Le stabilisateur d'émulsion peut principalement comprendre un copolymère séquencé de poly(oxyde d'éthylène). Ces émulsions de perfluorocarbone stabilisées peuvent être utilisées dans des phases liquides et/ou d'hydrogel de bioréacteurs de perfusion ou divers autres systèmes de culture pour améliorer la viabilité cellulaire dans des constructions de tissu épais, ou en tant que substituts sanguins, bien que d'autres applications puissent également être envisagées.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2373289US20110306581