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1. (WO2010077663) SUBSTITUTED TETRACYCLIC 1H-INDENO (1,2-B) PYRIDINE-2 (5H)-ONE ANALOGS THEREOF AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077663 International Application No.: PCT/US2009/067157
Publication Date: 08.07.2010 International Filing Date: 08.12.2009
IPC:
C07D 513/04 (2006.01) ,C07D 487/04 (2006.01) ,C07D 403/08 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/4738 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
08
linked by a carbon chain containing alicyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4738
ortho- or peri-condensed with heterocyclic ring systems
Applicants:
INOTEK PHARMACEUTICALS CORPORATION [US/US]; 100 Cummings Center, 4th Floor Beverly, MA 01915, US (AllExceptUS)
JAGTAP, Prakash [IN/US]; US (UsOnly)
PHAM-HUU, Duy-Phong [VN/US]; US (UsOnly)
COHEN, Frederick [US/US]; US (UsOnly)
HU, Huiyong [CN/US]; US (UsOnly)
WANG, Xiaojing [US/US]; US (UsOnly)
Inventors:
JAGTAP, Prakash; US
PHAM-HUU, Duy-Phong; US
COHEN, Frederick; US
HU, Huiyong; US
WANG, Xiaojing; US
Agent:
REMILLARD, Jane, E.; Lahive & Cockfield, LLP One Post Office Square Boston, MA 02109-2127, US
Priority Data:
61/201,28108.12.2008US
Title (EN) SUBSTITUTED TETRACYCLIC 1H-INDENO (1,2-B) PYRIDINE-2 (5H)-ONE ANALOGS THEREOF AND USES THEREOF
(FR) ANALOGUES TÉTRACYCLIQUES SUBSTITUÉS DE 1H-INDÉNO(1,2-B)PYRIDINE-2(5H)-ONE ET LEURS UTILISATIONS
Abstract:
(EN) Provided herein are tetracyclic 1H-indeno[1,2-b]pyridine-2(5H)-one analogs and derivatives, compositions comprising an effective amount of a tetracyclic 1H- indeno[1,2-b]pyridine-2(5H)-one analog and/or derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, a reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, an ocular or ophthalmologic disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, contrast induced nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of a tetracyclic 1H- indeno[1,2-b]pyridine-2(5H)-one analog or derivative.
(FR) La présente invention porte sur des analogues et dérivés tétracycliques de 1H-indéno[l,2-b]pyridine-2(5H)-one, sur des compositions comprenant une quantité efficace d'un analogue et/ou dérivé tétracyclique de 1H-indeno[l,2-b]pyridine-2(5H)-one et sur des méthodes de traitement ou de prévention d'une maladie inflammatoire, d'une lésion par reperfusion, du diabète sucré, d'une complication diabétique, d'une lésion par réoxygénation résultant d'une transplantation d'organe, d'un état ischémique, d'une maladie neurodégénérative, d'une insuffisance rénale, d'une maladie vasculaire, d'une maladie cardiovasculaire, d'une maladie oculaire ou ophtalmologique, d'un cancer, d'une complication de prématurité, d'une cardiomyopathie, d'une rétinopathie, d'une néphropathie, d'une néphropathie induite par les produits de contraste, d'une neuropathie, d'un dysfonctionnement érectile ou d'une incontinence urinaire, la méthode de traitement comprenant l'administration à un sujet en ayant besoin d'une quantité efficace d'un analogue ou dérivé tétracyclique de 1H-indéno[l,2-b]pyridine-2(5H)-one.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)