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1. (WO2010077634) ANTI-PD-L1 ANTIBODIES AND THEIR USE TO ENHANCE T-CELL FUNCTION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077634 International Application No.: PCT/US2009/067104
Publication Date: 08.07.2010 International Filing Date: 08.12.2009
Chapter 2 Demand Filed: 04.10.2010
IPC:
C07K 16/28 (2006.01) ,A61P 35/00 (2006.01) ,A61K 39/395 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Applicants:
GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (AE, AG, AL, AM, AO, AU, AZ, BA, BB, BF, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PE, PG, PH, RS, RU, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AT, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
IRVING, Bryan [US/US]; US (UsOnly)
CHEUNG, Jeanne [US/US]; US (UsOnly)
CHIU, Henry [US/US]; US (UsOnly)
LEHAR, Sophie, M. [US/US]; US (UsOnly)
MAECKER, Heather [US/US]; US (UsOnly)
MARIATHASAN, Sanjeev [CA/US]; US (UsOnly)
WU, Yan [US/US]; US (UsOnly)
Inventors:
IRVING, Bryan; US
CHEUNG, Jeanne; US
CHIU, Henry; US
LEHAR, Sophie, M.; US
MAECKER, Heather; US
MARIATHASAN, Sanjeev; US
WU, Yan; US
Agent:
SVOBODA, Craig, G.; Genentech, Inc. 1 DNA Way MS 49 South San Francisco, California 94080, US
Priority Data:
61/121,09209.12.2008US
Title (EN) ANTI-PD-L1 ANTIBODIES AND THEIR USE TO ENHANCE T-CELL FUNCTION
(FR) ANTICORPS ANTI-PD-L1 ET LEUR UTILISATION POUR AMÉLIORER LA FONCTION DES LYMPHOCYTES T
Abstract:
(EN) The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.
(FR) La présente invention concerne des anticorps anti-PD-L1, un acide nucléique les codant, leurs compositions thérapeutiques et leur utilisation pour améliorer la fonction des lymphocytes T en vue de réguler positivement les réponses immunitaires à médiation cellulaire et pour le traitement de troubles dysfonctionnels des lymphocytes T, y compris une infection (par ex. aiguë et chronique) et l'immunité tumorale.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
UAa201108595AR074563IL213353MXMX/a/2011/005853SG172059EP2376535
MA32948JP2012511329CR138/20110316CN102245640RU2011128399CA2740806
MX2011005853CO6390023SG2014001614CN104479018JP2015091260KR1020110092300
BRPI0917592NZ592119IL249127AU2009333580AU2016203867MX342591
DK2376535ES2628095VN27817VN49883JP2017136085ID051.3665
MYPI 2011002606TH123702KR1020170113681RU0002636023EP3255060IN3968/CHENP/2011
IN201648006749SG10201708690SAU2018203226KR1020180089573MX356367PT2376535
CR20160570IDP00201902918KR1020190069615