Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2010077624) BIARYL CARBOXAMIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077624 International Application No.: PCT/US2009/067080
Publication Date: 08.07.2010 International Filing Date: 08.12.2009
IPC:
A01N 43/90 (2006.01) ,A61K 31/519 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
90
having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
Applicants:
MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US (AllExceptUS)
OGAWA, Anthony [US/US]; US (UsOnly)
OK, Hyun, O. [US/US]; US (UsOnly)
ONDEYKA, Debra [US/US]; US (UsOnly)
UJJAINWALLA, Feroze [GB/US]; US (UsOnly)
VANDE BUNTE, Ellen [US/US]; US (UsOnly)
Inventors:
OGAWA, Anthony; US
OK, Hyun, O.; US
ONDEYKA, Debra; US
UJJAINWALLA, Feroze; US
VANDE BUNTE, Ellen; US
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Priority Data:
61/201,28309.12.2008US
Title (EN) BIARYL CARBOXAMIDES
(FR) BIARYL CARBOXAMIDES
Abstract:
(EN) This invention provides compounds of Formula (I) which are PAFR antagonists: Formula (I) and the pharmaceutically acceptable salts thereof. The compounds are useful for treating PAF-mediated disorders, and can be used in methods for treating atherosclerosis and preventing or reducing risk for atherosclerotic disease events. The compounds are also useful for treating or ameliorating pain, e.g. inflammatory pain and/or nociceptive pain, and for treating or ameliorating autoimmune and/or inflammatory diseases, among other conditions.
(FR) La présente invention porte sur des composés de formule (I) qui sont des antagonistes du récepteur du PAFR : formule (I) et sur les sels pharmaceutiquement acceptables de ceux-ci. Les composés sont utiles pour traiter des troubles médiés par le PAF, et peuvent être utilisés dans des procédés de traitement de l'athérosclérose et de prévention ou de réduction d'un risque d'événements de maladie athérosclérotique. Les composés sont également utiles pour traiter ou améliorer la douleur, par exemple la douleur inflammatoire et/ou la douleur nociceptive, et pour traiter ou améliorer des maladies auto-immunes et/ou inflammatoires, parmi d'autres états.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2375904US20110230498