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1. (WO2010077294) OLFACTORY STEM CELLS AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077294 International Application No.: PCT/US2009/006475
Publication Date: 08.07.2010 International Filing Date: 09.12.2009
IPC:
C12N 5/074 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
074
Adult stem cells
Applicants:
KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE [SA/SA]; P.O. Box 3354 Riyadh, 11211, MBC-03, SA (AllExceptUS)
ADRA, Chaker, N. [US/US]; US (UsOnly)
Inventors:
ADRA, Chaker, N.; US
Agent:
EL-HAYEK, Roque; Wolf, Greenfield & Sacks, P.C. Federal Reserve Plaza 600 Atlantic Avenue Boston, MA 02210-2206, US
Priority Data:
61/201,42709.12.2008US
Title (EN) OLFACTORY STEM CELLS AND USES THEREOF
(FR) CELLULES SOUCHES OLFACTIVES ET LEURS UTILISATIONS
Abstract:
(EN) Some aspects of this invention are based, at least in part, on the discoveries (i) pluripotent stem cell populations can be obtained from olfactory mucosa, (ii) that various regions of the olfactory mucosa contain pluripotent stem cells, (iii) that cells from these olfactory mucosa derived stem cell populations can be maintained in cultures containing EGF and/or bFGF, (iv) that cells from these olfactory mucosa derived stem cell populations are able to form neurospheres, and/or (v) that cells from these olfactory mucosa derived stem cell populations can differentiate into various lineages, including mesenchymal and neuronal lineages.
(FR) La présente invention, selon certains de ses aspects, concerne au moins en partie les découvertes suivantes : (i) des populations de cellules souches pluripotentes peuvent être obtenues à partir de muqueuse olfactive, (ii) diverses régions de la muqueuse olfactive contiennent des cellules souches pluripotentes, (iii) les cellules de ces populations de cellules souches issues de muqueuse olfactive peuvent être entretenues dans des cultures contenant EGF et/ou bFGF, (iv) les cellules de ces populations de cellules souches issues de muqueuse olfactive sont capables de former des neurosphères, et/ou (v) les cellules de ces populations de cellules souches issues de muqueuse olfactive peuvent se différencier en diverses lignées, notamment les lignées mésenchymateuses et neuronales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)