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1. (WO2010077260) PEGYLATED HEMOGLOBINS STABILIZED AT VALINE-1(ALPHA), METHODS OF PREPARATION AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077260 International Application No.: PCT/US2009/006079
Publication Date: 08.07.2010 International Filing Date: 12.11.2009
IPC:
A61K 38/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
Applicants:
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY [US/US]; 1300 Morris Park Avenue Bronx, NY 10461, US (AllExceptUS)
ACHARYA, Seetharama, A. [US/US]; US (UsOnly)
HU, Tao [CN/CN]; CN (UsOnly)
Inventors:
ACHARYA, Seetharama, A.; US
HU, Tao; CN
Agent:
MILLER, Alan, D.; Amster, Rothstein & Ebenstein LLP 90 Park Avenue New York, NY 10016, US
Priority Data:
61/201,19008.12.2008US
Title (EN) PEGYLATED HEMOGLOBINS STABILIZED AT VALINE-1(ALPHA), METHODS OF PREPARATION AND USES THEREOF
(FR) HÉMOGLOBINES PEGYLÉES STABILISÉES À LA VALINE-1 (ALPHA), LEURS PROCÉDÉS DE PRÉPARATION ET LEUR UTILISATION
Abstract:
(EN) Disclosed are PEGylated hemoglobins (Hbs) modified at Valine-1 (alpha) to increase tetramer stability of hemoglobin, methods of making these modified hemoglobins, and their use as blood substitutes.
(FR) L'invention porte sur des hémoglobines PEGylées (Hbs) modifiées à la valine-1(alpha) de façon à augmenter la stabilité des tétramères de l'hémoglobine, sur des procédés de production de ces hémoglobines modifiées et sur leur utilisation en tant que substituts sanguins.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)