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1. (WO2010077152) BIOLOGICAL OIL COMPOSITION, FORMULATIONS COMPRISING THE OIL COMPOSITION, AND USE THEREOF TO PREVENT OR TREAT CARDIOVASCULAR DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077152 International Application No.: PCT/NO2010/000002
Publication Date: 08.07.2010 International Filing Date: 04.01.2010
Chapter 2 Demand Filed: 03.11.2010
IPC:
A61K 31/122 (2006.01) ,A61K 31/202 (2006.01) ,A61K 31/232 (2006.01) ,A61P 9/00 (2006.01) ,A61P 9/10 (2006.01) ,A23D 9/00 (2006.01) ,A23L 1/30 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
122
having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
20
having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
202
having three or more double bonds, e.g. linolenic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
22
of acyclic acids, e.g. pravastatin
23
of acids having a carboxyl group bound to a chain of seven or more carbon atoms
232
having three or more double bonds, e.g. etretinate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
23
FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
D
EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
9
Other edible oils or fats, e.g. shortenings, cooking oils
A HUMAN NECESSITIES
23
FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
L
FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
1
Foods or foodstuffs; Their preparation or treatment
29
Modifying nutritive qualities of foods; Dietetic products
30
containing additives
Applicants:
CALANUS AS [NO/NO]; P.O. Box 2489 N-9272 Tromsø, NO (AllExceptUS)
RAA, Jan [NO/NO]; NO (UsOnly)
RØRSTAD, Gunnar [NO/NO]; NO (UsOnly)
TANDE, Kurt, Steinar [NO/NO]; NO (UsOnly)
Inventors:
RAA, Jan; NO
RØRSTAD, Gunnar; NO
TANDE, Kurt, Steinar; NO
Agent:
ONSAGERS AS; P.O. Box 6963 St. Olavs plass N-0130 Oslo, NO
Priority Data:
2009003305.01.2009NO
Title (EN) BIOLOGICAL OIL COMPOSITION, FORMULATIONS COMPRISING THE OIL COMPOSITION, AND USE THEREOF TO PREVENT OR TREAT CARDIOVASCULAR DISEASE
(FR) COMPOSITION D'HUILE BIOLOGIQUE, FORMULATIONS COMPRENANT LA COMPOSITION D'HUILE, ET UTILISATION DE CELLE-CI POUR PRÉVENIR OU TRAITER UNE MALADIE CARDIOVASCULAIRE
Abstract:
(EN) This invention relates to a biological oil composition, preferably obtained from a copepod, most preferably the copepod Calanus finmarchicus and the use thereof to prevent or treat formation of atherosclerotic plaques and hence development of coronary heart disease. The composition comprises the same marine n-3 polyunsaturated fatty acids (PUFAs) generally regarded as being responsible for the anti-atherosclerotic effect of marine oils, namely EPA (C20:5n-3 eicosapentaenoic acid) and DHA (C22:6n-3 docosahexaenoic acid). However, quite unexpectedly, it has been found that the oil composition of the present invention has a remarkably higher ability to prevent formation of atherosclerotic plaques than what can be attributed to EPA and DHA alone, and moreover, unlike EPA and DHA alone it has a notable blood cholesterol lowering effect.
(FR) La présente invention concerne une composition d'huile biologique, de préférence obtenue à partir d'un copépode, de manière préférée entre toutes le copépode Calanus finmarchicus et l'utilisation de celle-ci pour prévenir ou traiter la formation de plaques athéroscléreuses et par conséquent le développement d'une maladie coronarienne. La composition comprend les mêmes acides gras poly-insaturés (PUFA) n-3 marins généralement considérés comme étant responsables de l'effet anti-athérosclérotique des huiles marines, à savoir EPA (C20:5n-3 acide eicosapentaénoïque) et DHA (C22:6n-3 acide docosahexaénoïque). Cependant, de manière tout à fait inattendue, il a été observé que la composition d'huile de la présente invention a une capacité remarquablement supérieure à prévenir la formation de plaques athéroscléreuses à celle qui peut être attribuée à EPA et DHA seuls, et de plus, contrairement à EPA et DHA seuls, elle a un effet hypocholestérolémiant notable.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2384192JP2012514596US20110251276CN102271670RU2011130700CA2750153
US20140302128RU0002563995JP2015180640DK2384192IN4357/DELNP/2011ES2653940