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1. (WO2010077101) NOVEL THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/077101 International Application No.: PCT/KR2009/007995
Publication Date: 08.07.2010 International Filing Date: 30.12.2009
IPC:
C07D 277/34 (2006.01) ,C07D 277/36 (2006.01) ,C07D 417/12 (2006.01) ,C07D 413/12 (2006.01) ,A61K 31/427 (2006.01) ,A61K 31/426 (2006.01) ,A61P 9/00 (2006.01) ,A61P 9/12 (2006.01) ,A61P 17/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
34
Oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
427
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
14
for baldness or alopecia
Applicants:
조선대학교산학협력단 INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY [KR/KR]; 광주광역시 동구 서석동 375 375, Seosuk-dong Gwangju 501-759, KR (AllExceptUS)
조훈 CHO, Hoon [KR/KR]; KR (UsOnly)
무영 WU, Ying [CN/KR]; KR (UsOnly)
최철희 CHOI, Cheol-Hee [KR/KR]; KR (UsOnly)
Inventors:
조훈 CHO, Hoon; KR
무영 WU, Ying; KR
최철희 CHOI, Cheol-Hee; KR
Agent:
황주명 HWANG, Ju-Myung; 서울특별시 중구 태평로2가 120 대경빌딩 9층 Daekyung Building, 9th Floor 120, 2ka Taepyung-ro, Chung-gu Seoul 100-724, KR
Priority Data:
10-2008-013692130.12.2008KR
10-2009-005532622.06.2009KR
Title (EN) NOVEL THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF
(FR) NOUVEAU DÉRIVÉ DE THIAZOLIDINEDIONE ET SES APPLICATIONS
(KO) 신규한 티아졸리딘디온 유도체 및 그의 용도
Abstract:
(EN) The present invention relates to a novel Thiazolidinedione derivative expressed by the following chemical formula (1) and uses thereof. More specifically, the present invention relates to a novel Thiazolidinedione derivative expressed by the following chemical formula (1) and a pharmaceutical composition comprising the same. The novel Thiazolidinedione derivative of the following chemical formula (1) according to the present invention can be effectively used for the prevention or treatment of cardiovascular disease, gastrointestinal disease and renal disease by inhibiting the activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that decomposes prostaglandins, for preventing hair loss while stimulating hair growth, for osteogenic stimulation and for the treatment of burns.
(FR) La présente invention concerne un nouveau dérivé de thiazolidinedione de formule chimique (1) suivante et ses applications. Plus spécifiquement, la présente invention concerne un nouveau dérivé de thiazolidinedione de formule chimique (1) suivante et une composition pharmaceutique l'incluant. Le nouveau dérivé de thiazolidinedione de formule chimique (1) suivante selon la présente invention peut être employé efficacement dans le traitement prophylactique ou thérapeutique d'une maladie cardio-vasculaire, d'une maladie gastro-intestinale et d'une maladie rénale en inhibant l'activité de la 15-hydroxyprostaglandine déshydrogénase (15-PGDH) qui décompose les prostaglandines, dans la prévention de la chute de cheveux en stimulant la croissance capillaire, dans la stimulation ostéogène et dans le traitement des brûlures.
(KO) 본 발명은 하기 화학식 1로 표시되는 신규 화합물 및 그의 용도에 관한 것이다. 보다 구체적으로 본 발명은 하기 화학식 1로 표시되는 신규한 티아졸리딘디온 유도체 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명에 따른 하기 화학식 1의 신규한 티아졸리딘디온 유도체는 프로스타글란딘을 분해하는 15-하이드록시프로스타글란딘 탈수소화효소(15-PGDH)를 억제하는 활성을 나타내므로 심혈관계질환, 위장질환 및 신장질환을 예방 또는 치료하는데 효과적으로 사용될 수 있고, 탈모의 예방 및 발모 촉진에 효과적으로 사용될 수 있을 뿐만 아니라 골형성 촉진 및 화상 치료에도 효과적으로 사용할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)
Also published as:
EP2383263KR1020110107358US20110269954