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1. (WO2010076935) PHARMACEUTICAL COMPOSITION COMPRISING SIRNA SPECIFIC FOR REDUCED EXPRESSION-1 FOR TREATING THE BCNU-RESISTANCE GLIOBLASTOMA MULTIFORME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/076935 International Application No.: PCT/KR2009/004169
Publication Date: 08.07.2010 International Filing Date: 27.07.2009
IPC:
A61K 31/7105 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
7105
Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
Applicants:
SNU R&DB FOUNDATION [KR/KR]; San 4-2 Sillim-dong Gwanak-gu Seoul 151-010, KR (AllExceptUS)
KANG, Soo-Kyung [KR/KR]; KR (UsOnly)
Inventors:
KANG, Soo-Kyung; KR
Agent:
LEE, Won-Hee; 8th Fl. Sung-ji Heights II 642-16 Yoksam-dong Kangnam-ku Seoul 135-080, KR
Priority Data:
10-2008-013872531.12.2008KR
Title (EN) PHARMACEUTICAL COMPOSITION COMPRISING SIRNA SPECIFIC FOR REDUCED EXPRESSION-1 FOR TREATING THE BCNU-RESISTANCE GLIOBLASTOMA MULTIFORME
(FR) COMPOSITION PHARMACEUTIQUE COMPRENANT DE L'ARNSI SPÉCIFIQUE POUR EXPRESSION RÉDUITE 1 DESTINÉE À TRAITER LE GLIOBLASTOME MULTIFORME À RÉSISTANCE AU BCNU
Abstract:
(EN) The present invention relates to a pharmaceutical composition for treating BCNU(1,3-Bis(2-chloroethyl)-1-nitrosourea, Carmustine)-resistant glioblastoma multiforme, precisely a pharmaceutical composition comprising Rex-1 specific siRNA that is able to inhibit the expression of the stem cell marker Rex-1 (reduced expression-1) for inducing apoptosis of BCNU-resistant glioblastoma multiforme cells and for inhibiting tumor growth. The pharmaceutical composition of the present invention can be effectively used for the treatment of BCNU-resistant glioblastoma multiforme by co-administration with BCNU.
(FR) La présente invention porte sur une composition pharmaceutique destinée à traiter un gliome multiforme résistant au BCNU (1,3-bis(2-chloroéthyl)-1-nitrosourée, carmustine), précisément une composition pharmaceutique comprenant un ARNsi spécifique de Rex-1 capable d'inhiber l'expression du marqueur de cellule souche Rex-1 (expression 1 réduite) afin d'induire l'apoptose de cellule de glioblastome multiforme résistant au BCNU et d'inhiber la croissance tumorale. On peut utiliser efficacement la composition pharmaceutique de la présente invention pour le traitement d'un glioblastome multiforme résistant au BCNU par co-administration avec le BCNU.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)