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1. (WO2010076932) TNF-Α ANTAGONISTS CONTAINING IGFBP5
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/076932 International Application No.: PCT/KR2009/003570
Publication Date: 08.07.2010 International Filing Date: 30.06.2009
IPC:
A61K 48/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
성균관대학교산학협력단 SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION [KR/KR]; 경기 수원시 장안구 천천동 300 성균관대학교내 Sungkyunkwan Univ., 300, Cheoncheon-dong Jangan-gu Suwon-si Gyeonggi-do 440-746, KR (AllExceptUS)
이제호 LEE, Je-Ho [KR/KR]; KR (UsOnly)
황재령 HWANG, Jae-Ryoung [KR/KR]; KR (UsOnly)
허재호 HUH, Jae-Ho [KR/KR]; KR (UsOnly)
Inventors:
이제호 LEE, Je-Ho; KR
황재령 HWANG, Jae-Ryoung; KR
허재호 HUH, Jae-Ho; KR
Agent:
손민 SON, Min; 서울 강남구 삼성동 159-9 도심공항타워 6층 한얼국제특허사무소 Hanol Intellectual Property & Law 6th Floor, City Air Tower, 159-9 Samseong-dong, Gangnam-gu Seoul 135-973, KR
Priority Data:
10-2008-013816431.12.2008KR
Title (EN) TNF-Α ANTAGONISTS CONTAINING IGFBP5
(FR) ANTAGONISTES DU TNF-A CONTENANT L'IGFBP5
(KO) IGFBP5를 포함하는 TNF-α 길항제
Abstract:
(EN) The present invention relates to: TNF-α antagonists containing IGFBP5 protein, variants thereof, or fragments thereof; and the use of the TNF-α antagonists. More specifically, the present invention relates to: a polynucleotide encoding the protein, variants thereof, or fragments thereof; a vector containing the polynucleotide; a transformant containing the vector; and a method for screening a therapeutic agent for TNF-α overexpression-related diseases by checking whether the mutual reaction thereof is facilitated after treating with candidates to the cell expressing the IGFBP5 protein, variants thereof, or fragments thereof, and the TNFR1.
(FR) La présente invention concerne des antagonistes du TNF-α contenant la protéine IGFBP5, des variants de celle-ci, ou des fragments de celle-ci, ainsi que l'utilisation des antagonistes du TNF-α. Plus particulièrement, la présente invention concerne un polynucléotide codant pour la protéine, des variants de celle-ci, ou des fragments de celle-ci; un vecteur contenant le polynucléotide; un transformant contenant le vecteur; et un procédé pour le criblage d'un agent thérapeutique pour des maladies liées à la surexpression de TNF-α en vérifiant si la réaction mutuelle de celui-ci est facilitée suite à un traitement avec des candidats à la cellule exprimant la protéine IGFBP5, des variants de celle-ci, ou des fragments de celle-ci, et le TNFR1.
(KO) 본 발명은 IGFBP5 단백질, 이의 변이체, 또는 이들의 단편을 포함하는 TNF-α 길항제 및 이의 용도에 관한 것으로서 보다 구체적으로 상기 단백질, 이의 변이체 또는 이들의 단편을 코딩하는 폴리뉴클레오티드, 상기 폴리뉴클레오티드를 포함하는 벡터, 상기 벡터를 포함하는 형질전환체, 및 IGFBP5 단백질, 이의 변이체 또는 이들의 단편 및 TNFR1을 발현하는 세포에 후보물질을 처리한 후 이들의 상호작용 촉진 여부를 확인함으로써 TNF-α 과발현 관련 질환의 치료제를 스크리닝하는 방법에 관한 것이다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)
Also published as:
US20120046217