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1. (WO2010076805) NOVEL POLYMORPHS OF SUNITINIB MALATE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/076805 International Application No.: PCT/IN2009/000008
Publication Date: 08.07.2010 International Filing Date: 02.01.2009
IPC:
C07D 403/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
Applicants:
HETERO RESEARCH FOUNDATION [IN/IN]; Plot No . B- 80 & 81, A. P. I. E., Balanagar Hyderabad, Andhrapradesh Hyderabad 500 018, IN (AllExceptUS)
PARTHASARADHI REDDY, Bandi [IN/IN]; IN (UsOnly)
RATHNAKAR REDDY, Kura [IN/IN]; IN (UsOnly)
RAJI REDDY, Rapolu [IN/IN]; IN (UsOnly)
MURALIDHARA REDDY, Dasari [IN/IN]; IN (UsOnly)
SRINIVASA RAO, Thungathurthy [IN/IN]; IN (UsOnly)
Inventors:
PARTHASARADHI REDDY, Bandi; IN
RATHNAKAR REDDY, Kura; IN
RAJI REDDY, Rapolu; IN
MURALIDHARA REDDY, Dasari; IN
SRINIVASA RAO, Thungathurthy; IN
Priority Data:
Title (EN) NOVEL POLYMORPHS OF SUNITINIB MALATE
(FR) NOUVEAUX POLYMORPHES DE MALATE DE SUNITINIB
Abstract:
(EN) The present invention provides a novel crystalline form of sunitinib malate, process for its preparation and to pharmaceutical composition containing it. The present invention also provides a process for preparation of sunitinib malate crystal form I. Thus, for example, sunitinib malate was added to water, the mixture was heated to 80 deg C to obtain a clear solution and stirred for 30 minutes at 80 deg C, slowly cooled to room temperature and the solution was subjected to freez drying at about -90 deg C for 8 hours to give sunitinib malate crystalline form III.
(FR) La présente invention concerne une nouvelle forme cristalline de malate de sunitinib, un procédé pour se préparation et une composition pharmaceutique le contenant. L'invention concerne également un procédé de préparation de la forme cristalline I de malate de sunitinib. Un procédé consiste par exemple à ajouter du malate de sunitinib à de l'eau, chauffer le mélange à 80 °C pour obtenir une solution limpide et agiter pendant 30 minutes à 80 °C, refroidir lentement la solution à température ambiante, et la soumettre à une lyophilisation à environ –90 °C pendant 8 heures pour obtenir la forme cristalline III de malate de sunitinib.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2373643US20110306647EP2896618IN8470/CHENP/2010