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1. (WO2010076474) METHOD FOR PREPARING ACTIVATED ESTERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/076474 International Application No.: PCT/FR2009/052528
Publication Date: 08.07.2010 International Filing Date: 15.12.2009
IPC:
C07D 207/46 (2006.01) ,C07D 213/71 (2006.01) ,C07D 401/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
46
with hetero atoms directly attached to the ring nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62
Oxygen or sulfur atoms
70
Sulfur atoms
71
to which a second hetero atom is attached
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
SANOFI [FR/FR]; 174 avenue de France F-75013 Paris, FR (AllExceptUS)
BIGOT, Antony [FR/FR]; FR (UsOnly)
Inventors:
BIGOT, Antony; FR
Agent:
SENNINGER, Thierry; c/o sanofi Département Brevets 174 avenue de France F-75013 Paris, FR
Priority Data:
08/0709017.12.2008FR
Title (EN) METHOD FOR PREPARING ACTIVATED ESTERS
(FR) PROCEDE DE PREPARATION D'ESTERS ACTIVES
Abstract:
(EN) The invention relates to a method for preparing an activated ester of the formula (I), where R is a (C1-C6) alkyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl group, and ALK is a (C1-C6) alkylene group, said method consisting of reacting the dicyclohexylamine P1 salt and the disuccinimidyl carbonate (DSC) in a solvent in which the dicyclohexylamine salt of the N-hydroxysuccinimide P2 is precipitated. The invention also relates to products of the formula P1.
(FR) L'invention est relative à un procédé de préparation d'un ester activé de formule (I) dans laquelle R représente un groupe (C1-C6) alkyle, aryle, hétéroaryle, cycloalkyle, hétérocycloalkyle et AIk représente un groupe (C1-C6) alkylène, consistant à faire réagir le sel de dicyclohexylamine P1 : et le carbonate de disuccinimidyl e (DSC) dans un solvant dans lequel le sel dicyclohexylamine de la N-hydroxysuccinimide P2 précipite. L'invention est aussi relative aux produits de formule P1 :
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
RSP-2014/0198IL213525SG172179EP2379501JP2012512234US20110313168
CN102292318RU2011129652CA2747105ES2459918PT2379501MX2011006624
KR1020110094311BRPI0922972FR2939795DK2379501AU2009334689MYPI 2011002758
IN2436/KOLNP/2011