Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2010076433) NOVEL FLUORESCENT BORON-SUBSTITUTED DIPYRROMETHENES AND USE THEREOF FOR DIAGNOSIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/076433 International Application No.: PCT/FR2009/001486
Publication Date: 08.07.2010 International Filing Date: 28.12.2009
IPC:
C07F 5/02 (2006.01) ,G01N 33/68 (2006.01) ,C07K 14/47 (2006.01) ,C07H 23/00 (2006.01) ,C07F 9/6596 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
5
Compounds containing elements of the 3rd Group of the Periodic System
02
Boron compounds
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
23
Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6596
having atoms other than oxygen, sulfur, selenium, tellurium, nitrogen or phosphorus as ring hetero atoms
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR/FR]; 3, rue Michel Ange F-75016 Paris, FR (AllExceptUS)
UNIVERSITE DE STRASBOURG [FR/FR]; 4, rue Blaise Pascal CS 90032 F-67081 Strasbourg Cedex, FR (AllExceptUS)
DE BARRY, Jean [FR/FR]; FR (UsOnly)
LIEGEOIS, Corinne [FR/FR]; FR (UsOnly)
HAEFELE, Alexandre [FR/FR]; FR (UsOnly)
BURA, Thomas [FR/FR]; FR (UsOnly)
ULRICH, Gilles [FR/FR]; FR (UsOnly)
ZIESSEL, Raymond [FR/FR]; FR (UsOnly)
Inventors:
DE BARRY, Jean; FR
LIEGEOIS, Corinne; FR
HAEFELE, Alexandre; FR
BURA, Thomas; FR
ULRICH, Gilles; FR
ZIESSEL, Raymond; FR
Agent:
ORÈS, Béatrice; Cabinet Orès 36, rue de St Petersbourg F-75008 Paris, FR
Priority Data:
080747329.12.2008FR
Title (EN) NOVEL FLUORESCENT BORON-SUBSTITUTED DIPYRROMETHENES AND USE THEREOF FOR DIAGNOSIS
(FR) NOUVEAUX COMPOSES DIPYRROMETHENES-BOROSUBSTITUES FLUORESCENTS ET LEUR UTILISATION POUR LE DIAGNOSTIC
Abstract:
(EN) The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological molecules. The invention also relates to biological molecules marked with said fluorescent compounds, and to the use thereof in detection methods such as medical diagnosis methods. More particularly, the detection methods of the invention are particularly useful for diagnosing neurodegenerative diseases such as Alzheimer's disease.
(FR) La présente invention se rapporte ô de nouveaux composés fluorescents dérivés de dipyrrométhènes-bore non fluorés, leur procédé de préparation et leur utilisation pour le marquage fluorescent de molécules biologiques. L'invention se rapporte encore ô des molécules biologiques marquées avec lesdits composés fluorescents et leur utilisation dans des méthodes de détection telles que des méthodes de diagnostic médical; en particulier, les méthodes de détection selon l'invention s'avèrent particulièrement utiles pour le diagnostic de maladies neurodégénératives telles que la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
IL213832EP2384329JP2012513973US20110287473CN102300867CA2748313
BRPI0923871FR2940653AU2009334648IN1458/MUMNP/2011