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1. (WO2010076322) PREDICTION OF RESPONSE TO TAXANE/ANTHRACYCLINE-CONTAINING CHEMOTHERAPY IN BREAST CANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/076322 International Application No.: PCT/EP2009/067990
Publication Date: 08.07.2010 International Filing Date: 29.12.2009
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
SIVIDON DIAGNOSTICS GMBH; Nattermannallee 1 50829 Köln, DE (AllExceptUS)
KRONENWETT, Ralf [DE/DE]; DE (UsOnly)
VON TÖRNE, Christian [DE/DE]; DE (UsOnly)
BUDCZIES, Jan [DE/DE]; DE (UsOnly)
DENKERT, Carsten [DE/DE]; DE (UsOnly)
DIETEL, Manfred [DE/DE]; DE (UsOnly)
KOMOR, Martina [DE/DE]; DE (UsOnly)
LOIBL, Sibylle [DE/DE]; DE (UsOnly)
ROLLER, Marc [DE/DE]; DE (UsOnly)
VON MINCKWITZ, Gunther [DE/DE]; DE (UsOnly)
Inventors:
KRONENWETT, Ralf; DE
VON TÖRNE, Christian; DE
BUDCZIES, Jan; DE
DENKERT, Carsten; DE
DIETEL, Manfred; DE
KOMOR, Martina; DE
LOIBL, Sibylle; DE
ROLLER, Marc; DE
VON MINCKWITZ, Gunther; DE
Agent:
VON KREISLER, SELTING, WERNER; P.O. Box 102241 50462 Köln, DE
Priority Data:
08022559.230.12.2008EP
Title (EN) PREDICTION OF RESPONSE TO TAXANE/ANTHRACYCLINE-CONTAINING CHEMOTHERAPY IN BREAST CANCER
(FR) PRÉDICTION DE LA RÉPONSE À UNE CHIMIOTHÉRAPIE À BASE DE TAXANE/D'ANTHRACYCLINE LORS D'UN CANCER DU SEIN
Abstract:
(EN) A method for predicting a response to and/or benefit from chemotherapy in a patient suffering from cancer comprising the steps of (i) classifying a tumor into at least two classes, (ii) determining in a tumor sample the expression of at least one marker gene indicative of a response to chemotherapy for a tumor in each respective class, (iii) depending on said gene expression, predicting said response and/or benefit; wherein said at least one marker gene comprises a gene selected from the group consisting of TMSL8, ABCC1, EGFR, MVP, ACOX2, HER2/NEU, MYH11, TOB1, AKR1C1, ERBB4, NFKB1A, TOP2A, AKR1C3, ESR1, OLFM1, TOP2B, ALCAM, FRAP1, PGR, TP53, BCL2, GADD45A, PRKAB1, TUBA1A, C16orf45, HIF1A, PTPRC, TUBB, CA12, 1GKC, RACGAP1, UBE2C, CD14, 1KBKB, S100A7, VEGFA, CD247, KRT5, SEPT8, YBX1, CD3D, MAPK3, SLC2A1, CDKN1A, MAPT, SLC7A8, CHPT1, MLPH, SPON1, CXCL13, MMP1, STAT1, CXCL9, MMP7, STC2, DCN, MUC1, STMN1 and combinations thereof.
(FR) L'invention porte sur une méthode permettant de prédire une réponse à une chimiothérapie et/ou le bénéfice apportée par celle-ci chez un patient souffrant d'un cancer. La méthode comprend les étapes consistant à (i) classifier une tumeur en au moins deux classes, (ii) déterminer dans un échantillon de tumeur l'expression d'au moins un gène marqueur indicateur d'une réponse à une chimiothérapie pour une tumeur dans chaque classe respective, (iii) selon ladite expression génique, prédire ladite réponse et/ou ledit bénéfice; ledit ou lesdits gènes marqueurs comprenant un gène choisi dans le groupe constitué par les gènes TMSL8, ABCC1, EGFR, MVP, ACOX2, HER2/NEU, MYH11, TOB1, AKR1C1, ERBB4, NFKB1A, TOP2A, AKR1C3, ESR1, OLFM1, TOP2B, ALCAM, FRAP1, PGR, TP53, BCL2, GADD45A, PRKAB1, TUBA1A, C16orf45, HIF1A, PTPRC, TUBB, CA12, 1GKC, RACGAP1, UBE2C, CD14, 1KBKB, S100A7, VEGFA, CD247, KRT5, SEPT8, YBX1, CD3D, MAPK3, SLC2A1, CDKN1A, MAPT, SLC7A8, CHPT1, MLPH, SPON1, CXCL13, MMP1, STAT1, CXCL9, MMP7, STC2, DCN, MUC1, STMN1 et les associations de ceux-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)