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1. (WO2010075765) CEFDINIR ACID DOUBLE SALT AND ITS PREPARATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075765 International Application No.: PCT/CN2009/076164
Publication Date: 08.07.2010 International Filing Date: 29.12.2009
IPC:
C07D 501/22 (2006.01) ,A61K 31/546 (2006.01) ,A61P 31/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
501
Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14
Compounds having a nitrogen atom directly attached in position 7
16
with a double bond between positions 2 and 3
20
7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
22
with radicals containing only hydrogen and carbon atoms, attached in position 3
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
542
ortho- or peri-condensed with heterocyclic ring systems
545
Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine
546
containing further heterocyclic rings, e.g. cephalothin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
浙江奥默生物医药有限公司 ZHEJIANG ADAMERCK BIOPHARMLABS INC. [CN/CN]; 中国浙江省杭州 拱墅祥园路39号7栋 7 Dong Xiangyuan Road, Gongshu Hangzhou, Zhejiang 310011, CN (AllExceptUS)
漆又毛 QI, Youmao [CN/CN]; CN (UsOnly)
YE, Fengqi [CN/CN]; CN (UsOnly)
揭清 JIE, Qing [CN/CN]; CN (UsOnly)
QI, Yingbei [CN/CN]; CN (UsOnly)
张冯敏 ZHANG, Fengmin [CN/CN]; CN (UsOnly)
余葆春 YU, Baochun [CN/CN]; CN (UsOnly)
YE, Tianjian [CN/CN]; CN (UsOnly)
余美平 YU, Meiping [CN/CN]; CN (UsOnly)
Inventors:
漆又毛 QI, Youmao; CN
YE, Fengqi; CN
揭清 JIE, Qing; CN
QI, Yingbei; CN
张冯敏 ZHANG, Fengmin; CN
余葆春 YU, Baochun; CN
YE, Tianjian; CN
余美平 YU, Meiping; CN
Agent:
杭州天欣专利事务所 HANGZHOU TIAN XIN PATENT AGENT,INC.; 中国浙江省杭州 上城中河中路281号1601 1601 No. 281, Zhong He Zhong Road, Shangcheng Hangzhou, Zhejiang 310003, CN
Priority Data:
200810164211.331.12.2008CN
Title (EN) CEFDINIR ACID DOUBLE SALT AND ITS PREPARATION
(FR) DOUBLE SEL D'ACIDE DE CEFDINIR ET SA PRÉPARATION
(ZH) 头孢地尼酸式复盐化合物及制备方法
Abstract:
(EN) The invention provides an acid double salt of cefdinir. The acid double salt is obtained by reacting cefdinir with acid and alkali metal element or ammonium (including ammonia) compound or with acid salt. The cefdinir sulfate double salt is prepared when acid or acid salt is sulfate. The cefdinir phosphate double salt is prepared when acid or acid salt is phosphate. The cefdinir acid double salt of the present invention has the obvious advantages of good solubility and high bioavailability, and can be prepared into oral solid preparation or injection. The cefdinir acid double salt has the following structural general formula.
(FR) L'invention concerne un double sel d'acide de cefdinir. Le double sel d'acide est obtenu par réaction du cefdinir avec un acide et un élément métal alcalin ou un composé d'ammonium (comprenant l'ammoniac) ou avec un sel d'acide. Le double sel de sulfate de cefdinir est préparé lorsque l'acide ou le sel d'acide est le sulfate. Le double sel de phosphate de cefdinir est préparé lorsque l'acide ou le sel d'acide est le phosphate. Le double sel d'acide de cefdinir de la présente invention présente les avantages évidents de bonne solubilité et de biodisponibilité élevée, et peut être préparé sous forme de préparation solide orale ou d'injectable. Le double sel d'acide de cefdinir a la formule générale structurale suivante.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
EP2385054JP2012513957RU2011133302RU0002531276MX2011007006KR1020110110226
BRPI0924101IN5544/CHENP/2011