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1. (WO2010075664) A HIGHLY EFFICIENT AND LONG-ACTING SLOW-RELEASE FORMULATION OF POORLY SOLUBLE DRUGS AND PREPARATION METHOD THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075664 International Application No.: PCT/CN2009/001299
Publication Date: 08.07.2010 International Filing Date: 23.11.2009
IPC:
A61K 9/22 (2006.01) ,A61K 9/52 (2006.01) ,A61K 47/02 (2006.01) ,A61K 47/30 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
22
Sustained or differential release type
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
52
Sustained or differential release type
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
Applicants:
江苏大学 JIANGSU UNIVERSITY [CN/CN]; 中国江苏省镇江市丹徒路301号 No. 301 Dantu Road Zhenjiang Jiangsu 212013, CN (AllExceptUS)
徐希明 XU, Ximing [CN/CN]; CN (UsOnly)
余江南 YU, Jiangnan [CN/CN]; CN (UsOnly)
朱源 ZHU, Yuan [CN/CN]; CN (UsOnly)
曹霞 CAO, Xia [CN/CN]; CN (UsOnly)
Inventors:
徐希明 XU, Ximing; CN
余江南 YU, Jiangnan; CN
朱源 ZHU, Yuan; CN
曹霞 CAO, Xia; CN
Agent:
南京知识律师事务所 ZHISHI LAW FIRM OF INTELLECTUAL PROPERTY; 中国江苏省南京市新模范马路5号南京科技广场9楼B座 9F, Block B, Nanjing Sci-Tech Center 5# Xinmofan Road, Nanjing Jiangsu 210009, CN
Priority Data:
200810242994.231.12.2008CN
Title (EN) A HIGHLY EFFICIENT AND LONG-ACTING SLOW-RELEASE FORMULATION OF POORLY SOLUBLE DRUGS AND PREPARATION METHOD THEREOF
(FR) FORMULE À LIBÉRATION LENTE D'EFFICACITÉ ÉLEVÉE ET DE DURÉE D'ACTION PROLONGÉE DE MÉDICAMENTS FAIBLEMENT SOLUBLES ET SA MÉTHODE D'ÉLABORATION
(ZH) 难溶性药物高效长效缓释制剂及其制法
Abstract:
(EN) A slow-release formulation of poorly soluble drugs is disclosed. It consists of a solid dispersion of poorly soluble drugs, silicon dioxide nanoparticles carrying poorly soluble drugs, slow-release skeleton materials and a release accelerator in the mass ratio of 1:0.5-1.25:0.1-0.3:0.1-0.3. The solid dispersion of poorly soluble drugs comprises poorly soluble drugs, povidone K30, soybean lecithin and acrylic resin IV in the mass of 1:1-3:0.3-0.8:0.2-0.5.
(FR) La présente invention concerne une formule à libération lente de médicaments faiblement solubles. Elle est constituée d'une dispersion solide de médicaments faiblement solubles, de nanoparticules de dioxyde de silicium portant les médicaments faiblement solubles, de matériaux de squelette à libération prolongée et d'un accélérateur de libération dans un rapport massique 1 : 0,5-1,25 : 0,1-0,3 : 0,1-0,3. La dispersion solide de médicaments faiblement solubles comprend des médicaments faiblement solubles, de la povidone K30, de la lécithine de soja et de la résine acrylique IV dans un rapport massique 1 : 1-3 : 0,3-0,8 : 0,2-0,5.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
US20110250269