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1. (WO2010075663) A FORMULATION OF SILYMARIN WITH HIGH EFFICIENCY AND PROLONGED ACTION AND THE PREPARATION METHOD THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075663 International Application No.: PCT/CN2009/001298
Publication Date: 08.07.2010 International Filing Date: 23.11.2009
IPC:
A61K 31/357 (2006.01) ,A61K 9/22 (2006.01) ,A61K 9/52 (2006.01) ,A61K 47/02 (2006.01) ,A61K 47/30 (2006.01) ,A61P 1/16 (2006.01) ,A61P 31/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
357
having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
22
Sustained or differential release type
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
52
Sustained or differential release type
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants:
江苏大学 JIANGSU UNIVERSITY [CN/CN]; 中国江苏省镇江市丹徒路301号 No. 301 Dantu Road Zhenjiang Jiangsu 212013, CN (AllExceptUS)
徐希明 XU, Ximing [CN/CN]; CN (UsOnly)
余江南 YU, Jiangnan [CN/CN]; CN (UsOnly)
童珊珊 TONG, Shanshan [CN/CN]; CN (UsOnly)
朱源 ZHU, Yuan [CN/CN]; CN (UsOnly)
曹霞 CAO, Xia [CN/CN]; CN (UsOnly)
Inventors:
徐希明 XU, Ximing; CN
余江南 YU, Jiangnan; CN
童珊珊 TONG, Shanshan; CN
朱源 ZHU, Yuan; CN
曹霞 CAO, Xia; CN
Agent:
南京知识律师事务所 ZHISHI LAW FIRM OF INTELLECTUAL PROPERTY; 中国江苏省南京市新模范马路5号南京科技广场B座9楼 9F, Block B, Nanjing Sci-Tech Center 5# Xinmofan Road, Nanjing Jiangsu 210009, CN
Priority Data:
200810242988.731.12.2008CN
Title (EN) A FORMULATION OF SILYMARIN WITH HIGH EFFICIENCY AND PROLONGED ACTION AND THE PREPARATION METHOD THEREOF
(FR) FORMULATION DE SILYMARINE DE GRANDE EFFICACITÉ ET À ACTION PROLONGÉE, ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ
(ZH) 一种水飞蓟素高效长效制剂及其制法
Abstract:
(EN) A formulation of silymarin with high efficiency and prolonged action and the preparation method thereof are disclosed. Said formulation consists of a solid dispersion of silymarin, silicon dioxide nanoparticles of silymarin, sustained-release matrix materials and release accelerator, wherein the mass ratio of the solid dispersion, nanoparticles, matrix materials and accelerator is 1: 0.5~1.25: 0.1~0.3: 0.1~0.3. The drug loading rate of the nanopartiles of silymarin is 51.95-52.87%. The solid dispersion comprises silymarin, polyvidone K30, soybean phospholipid, acrylic resin IV in the mass ratio of 1: 1~3: 0.3~0.8: 0.2~0.5.
(FR) L'invention concerne une formulation de silymarine de grande efficacité et à action prolongée, et un procédé de préparation associe. Ladite formulation se compose d'une dispersion solide de silymarine, de nanoparticules de dioxyde de silicium contenant de la silymarine, de matériaux de matrice à libération prolongée et d'un accélérateur de libération, la proportion massique relative de la dispersion solide, des nanoparticules, des matériaux de matrice et de l'accélérateur étant de 1 : 0,5~1,25 : 0,1~0,3 : 0,1~0,3. Le taux de chargement de médicament des nanoparticules de silymarine est de 51,95-52,87 %. La dispersion solide comprend de la silymarine, de la polyvidone K30, un phospholipide de soja et de la résine acrylique IV dans une proportion massique de 1 : 1~3 : 0,3~0,8 : 0,2~0,5.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
US20110201680