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1. (WO2010075636) COMPOUNDS AND METHODS FOR TREATMENT OF INFLUENZA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075636 International Application No.: PCT/CA2009/001907
Publication Date: 08.07.2010 International Filing Date: 30.12.2009
IPC:
C07D 249/04 (2006.01) ,A61K 31/196 (2006.01) ,A61K 31/4192 (2006.01) ,A61P 31/16 (2006.01) ,C07C 275/70 (2006.01) ,C07C 335/36 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
249
Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02
not condensed with other rings
04
1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
196
the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4192
1,2,3-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
16
for influenza or rhinoviruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
275
Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
70
Compounds containing any of the groups e.g. isoureas
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
335
Thioureas, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
30
Isothioureas
36
having sulfur atoms of isothiourea groups bound to carbon atoms of six-membered aromatic rings
Applicants:
SIMON FRASER UNIVERSITY [CA/CA]; 8888 University Drive University-Industry Liaison Office, Multi-Tenant Facility Burnaby, British Columbia V5A 1S6, CA (AllExceptUS)
PINTO, Brian Mario [CA/CA]; CA (UsOnly)
MOHAN, Sankar [IN/CA]; CA (UsOnly)
Inventors:
PINTO, Brian Mario; CA
MOHAN, Sankar; CA
Agent:
CHATTERJEE, Alakananda; Gowling Lafleur Henderson LLP P.O. Box 30, Suite 2300, 550 Burrard Street Vancouver, British Columbia V6C 2B5, CA
Priority Data:
61/193,85630.12.2008US
Title (EN) COMPOUNDS AND METHODS FOR TREATMENT OF INFLUENZA
(FR) COMPOSÉS ET MÉTHODES POUR LE TRAITEMENT DU VIRUS INFLUENZA
Abstract:
(EN) The present invention provides in part a compound of Formula (I) or a pharmaceutically- acceptable salt or stereoisomer thereof: where R1 is selected from the group consisting of a substituted triazole group, a guanidine group, a urea group, a thiourea group, an amidine group, and N3; and R2 is selected from the group consisting of H, Me, Et and an amino acid, and methods and uses thereof.
(FR) La présente invention concerne pour partie un composé de Formule (I) ou l'un de ses sels ou stéréoisomères de qualité pharmaceutique : où R1 est choisi dans le groupe constitué par un groupement triazole substitué, un groupement guanidine, un groupement urée, un groupement thiourée, un groupement amidine et N3 ; et R2 est choisi dans le groupe constitué par H, Me, Et et un acide aminé, ainsi que leurs méthodes et applications.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20120010254