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1. (WO2010075590) MEDICAL IMPLANTS AND METHODS OF MAKING MEDICAL IMPLANTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075590 International Application No.: PCT/US2009/069603
Publication Date: 01.07.2010 International Filing Date: 28.12.2009
IPC:
A61L 31/08 (2006.01) ,A61L 31/16 (2006.01) ,A61L 31/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31
Materials for other surgical articles
08
Materials for coatings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31
Materials for other surgical articles
14
Materials characterised by their function or physical properties
16
Biologically active materials, e.g. therapeutic substances
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31
Materials for other surgical articles
08
Materials for coatings
10
Macromolecular materials
Applicants:
BATTELLE MEMORIAL INSTITUTE [US/US]; 902 Battelle Boulevard P.O. Box 999, MSIN K1-53 Richland, WA 99352, US (AllExceptUS)
SHAW, Wendy, J. [US/US]; US (UsOnly)
YONKER, Clement, R. [US/US]; US (UsOnly)
FULTON, John, L. [US/US]; US (UsOnly)
TARASEVICH, Barbara, J. [US/US]; US (UsOnly)
MCCLAIN, James [US/US]; US (UsOnly)
TAYLOR, Doug [US/US]; US (UsOnly)
MATSON, Dean W. [US/US]; US (UsOnly)
Inventors:
SHAW, Wendy, J.; US
YONKER, Clement, R.; US
FULTON, John, L.; US
TARASEVICH, Barbara, J.; US
MCCLAIN, James; US
TAYLOR, Doug; US
MATSON, Dean W.; US
Agent:
TAYLOR, Jennifer; Wells St. John P.S. 601 W 1st Avenue Suite 1300 Spokane, WA 99201, US
Priority Data:
61/140,91126.12.2008US
Title (EN) MEDICAL IMPLANTS AND METHODS OF MAKING MEDICAL IMPLANTS
(FR) IMPLANTS MÉDICAUX ET PROCÉDÉS DE FABRICATION ASSOCIÉS
Abstract:
(EN) A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio- absorbable polymer and/ or pharmaceutical agent is deposited over the bioactive agent.
(FR) La présente invention concerne un implant médical comportant un substrat avec une surface oxydée, un revêtement de dérivé de silane lié de façon covalente à la surface, et un agent bioactif lié de façon covalente au revêtement. L'invention concerne aussi un stent implantable comprenant un cœur de stent avec une surface oxydée recouverte d'une couche de dérivé de silane liée de façon covalente à la surface, une couche d'espacement comprenant du polyéthylène glycol (PEG) liée de façon covalente à la couche de dérivé de silane, et une protéine liée de façon covalente au PEG. L'invention concerne aussi un procédé de fabrication d'un implant médical qui consiste à obtenir un substrat comportant une surface, oxyder cette surface et la faire réagir avec un silane dérivé pour former un revêtement de silane lié de façon covalente à la surface, puis lier de façon covalente un agent bioactif au revêtement de silane. Dans des cas particuliers, un revêtement supplémentaire de polymère et/ou d'agent pharmaceutique bioabsorbables est déposé sur l'agent bioactif.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2384206CA2748273