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1. (WO2010075551) COMPOSITIONS OF MODULATORS OF THE WNT/BETA-CATENIN PATHWAY AND BENZAMIDE AND/OR HYDROXAMIC ACID DERIVATIVES TO TREAT BIPOLAR DISORDER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075551 International Application No.: PCT/US2009/069472
Publication Date: 01.07.2010 International Filing Date: 23.12.2009
IPC:
C07D 211/32 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
08
with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18
with substituted hydrocarbon radicals attached to ring carbon atoms
30
with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
32
by oxygen atoms
Applicants:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02139, US (AllExceptUS)
UNIVERSITY OF WASHINGTON [US/US]; Uw Tech Transfer 4311 11th Avenue Ne, Suite 500 Seattle, WA 98105-4608, US (AllExceptUS)
FASS, Daniel [US/US]; US (UsOnly)
HAGGARTY, Stephen [CA/US]; US (UsOnly)
SCOLNICK, Edward [US/US]; US (UsOnly)
MOON, Randall, T. [US/US]; US (UsOnly)
BIECHELE, Travis, L. [US/US]; US (UsOnly)
CAMP, Nathan, D. [US/US]; US (UsOnly)
Inventors:
FASS, Daniel; US
HAGGARTY, Stephen; US
SCOLNICK, Edward; US
MOON, Randall, T.; US
BIECHELE, Travis, L.; US
CAMP, Nathan, D.; US
Agent:
NOTO, Joseph, M.; Nixon Peabody Llp - Patent Group 1100 Clinton Square Rochester, NY 14604-1792, US
Priority Data:
61/140,72824.12.2008US
Title (EN) COMPOSITIONS OF MODULATORS OF THE WNT/BETA-CATENIN PATHWAY AND BENZAMIDE AND/OR HYDROXAMIC ACID DERIVATIVES TO TREAT BIPOLAR DISORDER
(FR) COMPOSITIONS DE MODULATEURS DE LA VOIE WNT/BÊTA-CATÉNINE ET DE DÉRIVÉS DU BENZAMIDE ET/OU DE L'ACIDE HYDROXAMIQUE ET LEUR UTILISATION DANS LE TRAITEMENT DE LA MALADIE BIPOLAIRE
Abstract:
(EN) The present invention is directed to a composition comprising a modulator of the Wnt/β-catenin pathway, such as a GSK-3 inhibitor, or a pharmaceutically acceptable salt thereof either with a benzamide derivative or a pharmaceutically acceptable salt thereof or with a hydroxamic acid or a pharmaceutically acceptable salt thereof. The present invention is also directed to a method of treating bipolar disorder in a subject by administering either a benzamide derivative or a hydroxamic acid to the subject under conditions effective to treat a bipolar disorder. A modulator of the Wnt/β-catenin pathway, such as a GSK-3 inhibitor, or a pharmaceutically acceptable salt thereof may also be administered to a subject.
(FR) La présente invention concerne une composition comprenant un modulateur de la voie Wnt/β-caténine, par exemple un inhibiteur de la GSK-3, ou l'un de ses sels pharmaceutiquement acceptables, et soit un dérivé du benzamide ou l'un de ses sels pharmaceutiquement acceptables, soit un acide hydroxamique ou l'un de ses sels pharmaceutiquement acceptables. La présente invention concerne aussi un procédé de traitement de la maladie bipolaire chez un patient en lui administrant soit un dérivé du benzamide, soit un acide hydroxamique, dans des conditions propres à traiter la maladie bipolaire. Il est également possible d'administrer à un patient un modulateur de la voie Wnt/β-caténine, par exemple un inhibiteur de la GSK-3, ou l'un de ses sels pharmaceutiquement acceptables.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20130039998