PATENTSCOPE will be unavailable a few hours for maintenance reason on Tuesday 19.11.2019 at 4:00 PM CET
Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2010075520) PREPARATION OF GABAPENTIN ENACARBIL INTERMEDIATE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075520 International Application No.: PCT/US2009/069424
Publication Date: 01.07.2010 International Filing Date: 23.12.2009
IPC:
C07C 269/04 (2006.01) ,C07C 269/06 (2006.01) ,C07C 271/22 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
269
Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
04
from amines with formation of carbamate groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
269
Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
by reactions not involving the formation of carbamate groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
Esters of carbamic acids
08
having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10
with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
22
to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Applicants:
TEVA PHARMACEUTICAL INDUSTRIES LTD. [IL/IL]; Basel Street 5 P.O. Box 3190 49131 Petach-Tikva, IL (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 Horsham Road P.O. Box 1090 North Wales, PA 19454-1090, US (BB)
BEN MOHA-LERMAN, Elena [IL/IL]; IL (UsOnly)
BALANOV, Anna [IL/IL]; IL (UsOnly)
ADLER, Miri [IL/IL]; IL (UsOnly)
Inventors:
BEN MOHA-LERMAN, Elena; IL
BALANOV, Anna; IL
ADLER, Miri; IL
Agent:
WALLACE, W., David; Merchant & Gould P.C. P.O. Box 2903 Minneapolis, MN 55402-0903, US
Priority Data:
61/203,54623.12.2008US
Title (EN) PREPARATION OF GABAPENTIN ENACARBIL INTERMEDIATE
(FR) PRÉPARATION D'INTERMÉDIAIRE DE GABAPENTINE ENACARBIL
Abstract:
(EN) Allyl 1 {[(α-isobutanoyloxyethoxy)carbonyl] aminomethyl} -1-cyclohexane acetate can be prepared by combining allyl 1-aminomethyl-1-cyclohexane acetate hydrochloride, a polar organic solvent, chloroethyl chloroformate, and an amine base or an inorganic base selected from a group consisting of carbonate and bicarbonate to provide a reaction mixture; and adding isobutyric acid to the reaction mixture. The product can be purified and/or converted to gabapentin enacarbil.
(FR) L'acétate d'allyle 1 {[(α-isobutanoyloxyéthoxy)carbonyl] aminométhyl} -1-cyclohexane peut être préparé en combinant du chlorhydrate d'acétate d'allyle 1-aminométhyl-1-cyclohexane, un solvant organique polaire, du chloroformate de chloroéthyle et une base aminée ou une base inorganique sélectionnée dans un groupe constitué de carbonate et de bicarbonate afin de fournir un mélange réactionnel, et en ajoutant de l'acide isobutyrique au mélange réactionnel. Le produit peut être purifié et/ou converti en gabapentine enacarbil.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)