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1. (WO2010075449) MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075449 International Application No.: PCT/US2009/069305
Publication Date: 01.07.2010 International Filing Date: 22.12.2009
IPC:
G01N 30/72 (2006.01) ,G01N 33/483 (2006.01) ,A61K 38/22 (2006.01) ,B01D 59/44 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02
Column chromatography
62
Detectors specially adapted therefor
72
Mass spectrometers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
59
Separation of different isotopes of the same chemical element
44
Separation by mass spectrography
Applicants:
QUEST DIAGNOSTICS INVESTMENTS INCORPORATED [US/US]; 300 Delaware Avenue Wilmington, Delaware 19899, US (AllExceptUS)
GHOSHAL, Amit [CA/US]; US (UsOnly)
CLARKE, Nigel J. [GB/US]; US (UsOnly)
GOLDMAN, Mildred M. [US/US]; US (UsOnly)
Inventors:
GHOSHAL, Amit; US
CLARKE, Nigel J.; US
GOLDMAN, Mildred M.; US
Agent:
WARBURG, Richard; Foley & Lardner LLP 11250 El Camino Real, Suite 200 San Diego, California 92130, US
Priority Data:
61/140,82424.12.2008US
Title (EN) MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA
(FR) ANALYSE PAR SPECTROMÉTRIE DE MASSE POUR L'HYPERPLASIE SURRÉNALE CONGÉNITALE
Abstract:
(EN) Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
(FR) L'invention concerne des procédés permettant de détecter la quantité d'une ou de plusieurs substances à analyser de liste CAH (c'est-à-dire, prégnènolone, 17-OH prégnènolone, progestérone, 17-OH progestérone, déhydroépiandrostérone (DHEA), androstènedione, testostérone, désoxycortone, 11-désoxycortone et cortisol) dans un échantillon par spectrométrie de masse. Les procédés consistent généralement à ioniser une ou plusieurs substances à analyser de liste CAH dans un échantillon et à quantifier les ions générés pour déterminer la quantité de ladite ou desdites substances à analyser dans l'échantillon. Dans les procédés dans lesquels des quantités de multiples substances à analyser de liste CAH sont détectées, les quantités de substances à analyser multiples sont détectées dans la même injection d'échantillon.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2384437