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1. (WO2010075287) COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN AND OTHER DISEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075287 International Application No.: PCT/US2009/069005
Publication Date: 01.07.2010 International Filing Date: 21.12.2009
IPC:
C07D 409/12 (2006.01) ,A61K 31/381 (2006.01) ,A61K 31/404 (2006.01) ,A61P 19/02 (2006.01) ,A61P 29/00 (2006.01) ,A61P 21/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
38
having sulfur as a ring hetero atom
381
having five-membered rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
Applicants:
AQUILUS PHARMACEUTICALS, INC [US/US]; 225 Mystic Valley Parkway Winchester, MA 01890, US (AllExceptUS)
SUCHOLEIKI, Irving [US/US]; US
Inventors:
SUCHOLEIKI, Irving; US
Agent:
COHEN, Jerry; Burns & Levinson, LLP 125 Summer Street Boston, MA 02110, US
Priority Data:
61/203,54823.12.2008US
61/214,86329.04.2009US
Title (EN) COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN AND OTHER DISEASES
(FR) COMPOSÉS ET PROCÉDÉS POUR LE TRAITEMENT DE LA DOULEUR ET D'AUTRES MALADIES
Abstract:
(EN) The present invention relates generally to alkyne containing pharmaceutical agents, and in particular, to phenylethynyl-thiophene based metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of MMP inhibiting compounds that exhibit increased potency, metabolic stability and/or reduced toxicity in relation to currently known MMP inhibitors for the treatment of pain and other diseases such as cancer. Additionally, the present invention relates to methods for treating pain in a patient comprising administering to the patient a pain-reducing effective amount of a present compound.
(FR) La présente invention concerne de manière générale des agents pharmaceutiques contenant des alkynes, en particulier, des composés inhibiteurs de métalloprotéase à base de phényléthynyl-thiophène. Plus particulièrement, la présente invention concerne une nouvelle classe de composés inhibant MMP qui présentent une efficacité accrue, une stabilité métabolique et/ou une toxicité réduite par rapport aux inhibiteurs de MMP actuellement connus pour le traitement de la douleur et d'autres maladies, comme le cancer. En outre, la présente invention concerne des procédés de traitement de la douleur chez un patient comprenant l'administration au patient d'une quantité efficace pour réduire la douleur d'un présent composé.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL213703MXMX/a/2011/006791EP2382206JP2012513472US20110257222CN102325768
RU2011130381CA2747957RU0002528333KR1020110117088BRPI0923688ES2575689
AU2009330131IN1349/MUMNP/2011