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1. (WO2010075203) GAMMA SECRETASE MODULATORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075203 International Application No.: PCT/US2009/068684
Publication Date: 01.07.2010 International Filing Date: 18.12.2009
IPC:
C07D 498/04 (2006.01) ,A61K 31/4245 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245
Oxadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
SCHERING CORPORATION [US/US]; 126 East Lincoln Avenue RY60-30 Rahway, NJ 07065, US (AllExceptUS)
ASBEROM, Theodros [US/US]; US (UsOnly)
HUANG, Xianhai [CN/US]; US (UsOnly)
ZHU, Zhaoning [US/US]; US (UsOnly)
CLADER, John, W. [US/US]; US (UsOnly)
PISSARNITSKI, Dmitri, A. [US/US]; US (UsOnly)
JOSIEN, Hubert, B. [US/US]; US (UsOnly)
LI, Hongmei [CN/US]; US (UsOnly)
Inventors:
ASBEROM, Theodros; US
HUANG, Xianhai; US
ZHU, Zhaoning; US
CLADER, John, W.; US
PISSARNITSKI, Dmitri, A.; US
JOSIEN, Hubert, B.; US
LI, Hongmei; US
Agent:
JEANETTE, Henry, C.; Schering-Plough Corporation Patent Department, K-6-1 1990 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530, US
Priority Data:
61/139,66522.12.2008US
Title (EN) GAMMA SECRETASE MODULATORS
(FR) MODULATEURS DE GAMMA SECRÉTASE
Abstract:
(EN) This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (Chemical formula should be inserted here as it appears on abstract in paper form). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).
(FR) Cette invention porte sur de nouveaux composés qui sont des modulateurs de la gamma secrétase. Les composés ont la formule (la formule chimique devrait être introduite ici telle qu'elle apparait sur l'abrégé sous forme papier). L'invention porte également sur des procédés de modulation de l'activité de la gamma secrétase et des procédés de traitement de la Maladie d'Alzheimer à l'aide des composés de formule (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2379563JP2012513399US20110294784CA2747744AU2009330233