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1. (WO2010075200) 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075200 International Application No.: PCT/US2009/068672
Publication Date: 01.07.2010 International Filing Date: 18.12.2009
IPC:
C07D 405/12 (2006.01) ,C07D 405/14 (2006.01) ,C07D 413/12 (2006.01) ,C07D 417/12 (2006.01) ,A61K 31/353 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
353
3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
ARRAY BIOPHARMA INC. [US/US]; 3200 Walnut Boulder, Colorado 80301, US (AllExceptUS)
COOK, Adam [US/US]; US (UsOnly)
HUNT, Kevin, W. [US/US]; US (UsOnly)
DELISLE, Robert Kirk [US/US]; US (UsOnly)
ROMOFF, Todd [US/US]; US (UsOnly)
CLARK, Christopher, T. [US/US]; US (UsOnly)
KIM, Ganghyeok [US/US]; US (UsOnly)
CORRETTE, Christopher, P. [US/US]; US (UsOnly)
DOHERTY, George, A. [US/US]; US (UsOnly)
BURGESS, Laurence, E. [US/US]; US (UsOnly)
Inventors:
COOK, Adam; US
HUNT, Kevin, W.; US
DELISLE, Robert Kirk; US
ROMOFF, Todd; US
CLARK, Christopher, T.; US
KIM, Ganghyeok; US
CORRETTE, Christopher, P.; US
DOHERTY, George, A.; US
BURGESS, Laurence, E.; US
Agent:
HARRIS, Robert, J.; Viksnins Harris & Padys LLP P.O. Box 111098 St. Paul, MN 55111-1098, US
Priority Data:
61/139,98122.12.2008US
Title (EN) 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES
(FR) DÉRIVÉS D'ACIDE 7-PHÉNOXYCHROMANECARBOXYLIQUE
Abstract:
(EN) Compounds of Formula I: (I) in which A, A1, R1, R7a, R7b, R8 and R10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treatment and prevention of immunologic diseases, allergic diseases such as asthma, allergic rhinitis and atopic dermatitis, and other inflammatory diseases mediated by prostaglandin D2 (PGD2). The compounds of Formula I may also be useful in treating diseases or medical conditions involving the Th2 T cell via production of IL-4, IL-5 and/or IL-13.
(FR) Les composés de Formule I : (I) où A, A1, R1, R7a, R7b, R8 et R10 ont les valeurs données dans la description, sont des inhibiteurs de récepteur DP2 pouvant être employés dans le traitement prophylactique et thérapeutique de maladies immunologiques, de maladies allergiques comme l'asthme, la rhinite allergique et la dermatite atopique, et d'autres maladies inflammatoires faisant intervenir la prostaglandine D2 (PGD2). Les composés de Formule I peuvent également être employés dans le traitement de pathologies ou d'états pathologiques impliquant les cellules T Th2 via la production de IL-4, IL-5 et/ou IL-13.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2379535JP2012513398US20120101103CN102325767CA2748099IN3091/KOLNP/2011