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1. (WO2010075080) A METHOD OF TREATING INSOMNIA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/075080 International Application No.: PCT/US2009/068053
Publication Date: 01.07.2010 International Filing Date: 15.12.2009
IPC:
A01N 43/90 (2006.01) ,A61K 31/519 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
90
having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
Applicants:
SOMNUS THERAPEUTICS, INC. [US/US]; 135 Route 202/206 Bedminster, NJ 07921, US (AllExceptUS)
CUPIT, Gary [US/US]; US (UsOnly)
MCCORMICK, Anne [US/US]; US (UsOnly)
OSBAKKEN, Mary [US/US]; US (UsOnly)
BLUMHARDT, Christine [US/US]; US (UsOnly)
Inventors:
CUPIT, Gary; US
MCCORMICK, Anne; US
OSBAKKEN, Mary; US
BLUMHARDT, Christine; US
Agent:
KOLESAR, Dana, M.; Morgan, Lewis & Bockius LLP 1701 Market Street Philadephia, PA 19103-2921, US
Priority Data:
61/201,84415.12.2008US
61/201,85315.12.2008US
61/201,90415.12.2008US
61/201,91715.12.2008US
Title (EN) A METHOD OF TREATING INSOMNIA
(FR) MÉTHODE DE TRAITEMENT DES INSOMNIES
Abstract:
(EN) A method of treating insomnia comprising administering to a subject a formulation including zaleplon, wherein the formulation is adapted to release the zaleplon after a lag time of at least about one hour after administration of the formulation, and during which substantially no drug substance is released; provide a time of peak plasma concentration of about 3 hours to about 6 hours after administration; provide an elimination half-life after the time of peak plasma concentration of about 0.5 hours to about 0.3 hours; and provide an area under the curve of about 70 ng⋅h/mL to about 90 ng⋅h/mL.
(FR) L'invention concerne une méthode de traitement des insomnies comprenant l'administration à un sujet d'une formule incluant du zaleplon, la formule étant adaptée à la libération du zaleplon après un temps de latence d'au moins une heure après administration de la formule, pendant lequel substantiellement aucune substance médicamenteuse n'est libérée, et la formule permettant d'obtenir un temps de concentration plasmatique maximale compris entre environ 3 heures et environ 6 heures après administration. La méthode selon l'invention permet d'obtenir un temps de demi-vie d'élimination après la concentration plasmatique maximale compris entre environ 0,5 heure et environ 0,3 heure, ainsi qu'une aire sous la courbe comprise entre environ 70 ng.h/mL et environ 90 ng.h/mL.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2375903US20120039954CA2746884