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1. (WO2010074607) ACTIVE SUBSTANCE AND PHARMACEUTICAL COMPOSITION FOR TREATING ALCOHOL DEPENDENCE, AND A METHOD FOR OBTAINING AND THE USE OF SAID ACTIVE SUBSTANCE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/074607 International Application No.: PCT/RU2009/000691
Publication Date: 01.07.2010 International Filing Date: 15.12.2009
Chapter 2 Demand Filed: 05.07.2010
IPC:
C07D 235/28 (2006.01) ,C07D 403/12 (2006.01) ,C07D 413/12 (2006.01) ,C07D 405/12 (2006.01) ,C07D 403/04 (2006.01) ,C07D 401/12 (2006.01) ,C07D 401/14 (2006.01) ,C07D 487/04 (2006.01) ,C07D 409/12 (2006.01) ,A61K 31/4164 (2006.01) ,A61K 31/5377 (2006.01) ,A61K 31/454 (2006.01) ,A61K 31/4245 (2006.01) ,A61K 31/4192 (2006.01) ,A61K 31/4439 (2006.01) ,A61K 31/4985 (2006.01) ,A61P 25/32 (2006.01) ,A61P 25/24 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
235
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02
condensed with carbocyclic rings or ring systems
04
Benzimidazoles; Hydrogenated benzimidazoles
24
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
28
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5377
not condensed and containing further heterocyclic rings, e.g. timolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
454
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245
Oxadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4192
1,2,3-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
30
for treating abuse or dependence
32
Alcohol-abuse
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
24
Antidepressants
Applicants:
АЛЛА XEM, ЛЛС ALLA CHEM, LLC [US/US]; 318 H, Карсон Стриит, Свит 208, Карсон Сити, Невада 318 N, Carson Street, Suite 208 Carson City, Nevada 89701, US (AllExceptUS)
ИВАЩЕНКО Андрей Александрович IVASHCHENKO Andrey Alexandrovich [RU/RU]; RU
ИВАЩЕНКО, Александр Васильевич IVACHTCHENKO, Alexandre Vasilievich [RU/US]; US (UsOnly)
САВЧУК Николай Филиппович SAVCHUK Nikolay Filippovich [RU/US]; US (UsOnly)
Inventors:
ИВАЩЕНКО Андрей Александрович IVASHCHENKO Andrey Alexandrovich; RU
ИВАЩЕНКО, Александр Васильевич IVACHTCHENKO, Alexandre Vasilievich; US
САВЧУК Николай Филиппович SAVCHUK Nikolay Filippovich; US
Priority Data:
200814907615.12.2008RU
Title (EN) ACTIVE SUBSTANCE AND PHARMACEUTICAL COMPOSITION FOR TREATING ALCOHOL DEPENDENCE, AND A METHOD FOR OBTAINING AND THE USE OF SAID ACTIVE SUBSTANCE
(FR) SUBSTANCE ACTIVE ET COMPOSITION PHARMACEUTIQUE POUR LE TRAITEMENT DE LA DÉPENDANCE À L'ALCOOL, PROCÉDÉ DE PRODUCTION ET APPLICATIONS
(RU) ДЕЙСТВУЮЩЕЕ ВЕЩЕСТВО И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ЛЕЧЕНИЯ АЛКОГОЛЬНОЙ ЗАВИСИМОСТИ, СПОСОБ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
Abstract:
(EN) The invention relates to an active substance for treating alcohol dependence, a pharmaceutical composition, a medicinal agent and a method for treating dependence on the consumption of products containing ethyl alcohol. An active substance is proposed for treating alcohol dependence in humans and warm-blooded animals, comprising substituted 1H-benzimidazoles of the general formula 1 or the pharmaceutically acceptable salts and/or hydrates thereof, in which W denotes an atom of sulphur or the group S=O; R1 denotes one or more substituents selected from hydrogen, halogen, C1-C4 alkyl, C1-C4 alkyloxy, optionally substituted azaheterocyclyl; R2 denotes hydrogen or optionally substituted C1-C4 alkyl; R3 and R4 independently of one another denote optionally identical substituents selected from hydrogen or optionally substituted C1-C4 alkyl; R5 denotes an alkyl substituent selected from hydrogen, optionally substituted C1-C7 alkyl, optionally substituted aryl, optionally substituted heterocyclyl, C1-C4 alkoxycarbonyl, or optionally substituted aminocarbonyl.
(FR) L'invention concerne une substance active pour le traitement de la dépendance à l'alcool, ainsi qu'une composition pharmaceutique, un médicament, et un procédé de traitement de la dépendance à l'alcool liée à la consommation de produits contenant de l'alcool éthylique. La substance active pour le traitement de la dépendance à l'alcool chez les humains et les animaux à sang chaud consiste en un mélange de 1H-benzimidazoles correspondant à la formule générale I ou de leurs sels et/ou hydrates pharmaceutiquement acceptables, dans laquelle : W est un atome de soufre ou un groupe S=O; R1 représente un ou plusieurs substituants choisis parmi hydrogène, halogène, alkyle C1-C4, alkyloxy C1-C4, ou un azahétérocycle éventuellement substitué; R2 représente hydrogène ou un alkyle C1-C4 éventuellement substitué; R3 et R4 représentent indépendamment l'un de l'autre des substituants éventuellement identiques choisis parmi hydrogène et un alkyle C1-C4 éventuellement substitué; R5 représente un substituant alkyle choisi parmi hydrogène, un alkyle C1-C7 éventuellement substitué, un aryle éventuellement substitué, un hétérocyclyle éventuellement substitué, un alcoxycarbonyle C1-C4, et un aminocarbonyle éventuellement substitué.
(RU) Изобретение относится к действующему веществу для лечения алкогольной зависимости, фармацевтической композиции, лекарственному средству и способу лечения алкогольной зависимости от употребления продуктов, содержащих этиловый спирт. Предложено действующее вещество для лечения алкогольной зависимости людей и теплокровных животных, представляющее собой замещенные 1H-бензимидазолы общей формулы 1 или их фармацевтически приемлемые соли и/или гидраты где: W представляет собой атом серы или группу S=O; R1 представляет собой один или более заместителей, выбранных из водорода, галогена, C1-C4 алкила, C1-C4 алкилокси, необязательно замещенного азагетероциклила; R2 представляет собой водород или необязательно замещенный C1-C4 алкил; R3 и R4 независимо друг от друга представляют собой необязательно одинаковые заместители, выбранные из водорода или необязательно замещенного C1-C4 алкила; R5 представляет собой алкильный заместитель, выбранный из водорода, необязательно замещенного C1-C7 алкила, необязательно замещенного арила, необязательно замещенного гетероциклила, C1-C4 алкоксикарбонила, необязательно замещенного аминокарбонила.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Russian (RU)
Filing Language: Russian (RU)
Also published as:
UAa201108160US20110245231EA201100817