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1. (WO2010074453) COMPOSITION FOR TREATING GOUT, CONTAINING ANGELICA GIGAS EXTRACT HAVING A XANTHINE OXIDASE-INHIBITING EFFECT AND AN INFLAMMATION-INDUCING ENZYME-INHIBITING EFFECT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/074453 International Application No.: PCT/KR2009/007549
Publication Date: 01.07.2010 International Filing Date: 16.12.2009
IPC:
A61K 36/232 (2006.01) ,A61P 29/00 (2006.01) ,A61K 36/00 (2006.01) ,A61K 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
23
Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
232
Angelica
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
Applicants:
한국생명건강(주) KOREA BIO HEALTH CO., LTD. [KR/KR]; 경상남도 김해시 어방동 607 인제대학교 내 성산관 창업보육센터 909 909 In-je University Business Incubator Center Seongsangwan Eobang-dong Gimhae-si Gyeongsangnam-do 621-749, KR (AllExceptUS)
강재선 KANG, Jae Seon [KR/KR]; KR (UsOnly)
이진영 LEE, Jin Young [KR/KR]; KR (UsOnly)
박윤정 PARK, Yun Jung [KR/KR]; KR (UsOnly)
박재연 PARK, Jae Yeon [KR/KR]; KR (UsOnly)
김강민 KIM, Kang Min [KR/KR]; KR (UsOnly)
박민희 PARK, Min Hui [KR/KR]; KR (UsOnly)
김익환 KIM, Ik Hwan [KR/KR]; KR (UsOnly)
홍용근 HONG, Yong Geun [KR/KR]; KR (UsOnly)
정민수 JEONG, Min Su [KR/KR]; KR (UsOnly)
정우식 JEONG, Woo Sik [KR/KR]; KR (UsOnly)
옥선 OK, Seon [KR/KR]; KR (UsOnly)
Inventors:
강재선 KANG, Jae Seon; KR
이진영 LEE, Jin Young; KR
박윤정 PARK, Yun Jung; KR
박재연 PARK, Jae Yeon; KR
김강민 KIM, Kang Min; KR
박민희 PARK, Min Hui; KR
김익환 KIM, Ik Hwan; KR
홍용근 HONG, Yong Geun; KR
정민수 JEONG, Min Su; KR
정우식 JEONG, Woo Sik; KR
옥선 OK, Seon; KR
Agent:
김중효 KIM, Joong-Hyo; 서울특별시 강남구 역삼동 649-8 민석빌딩 4층 4th Fl, Minseok Bldg, 649-8 Yeoksam-dong, Gangnam-gu Seoul 135-912, KR
Priority Data:
10-2008-013259223.12.2008KR
Title (EN) COMPOSITION FOR TREATING GOUT, CONTAINING ANGELICA GIGAS EXTRACT HAVING A XANTHINE OXIDASE-INHIBITING EFFECT AND AN INFLAMMATION-INDUCING ENZYME-INHIBITING EFFECT
(FR) COMPOSITION POUR TRAITER LA GOUTTE, CONTENANT UN EXTRAIT D'ANGELICA GIGAS À EFFET INHIBANT LA XANTHINE OXYDASE ET LES ENZYMES À L'ORIGINE DES INFLAMMATIONS
(KO) 잔틴 산화효소 저해효과 및 염증유발효소 저해효과가 있는 참당귀 추출물을 포함하는 통풍 치료용 조성물
Abstract:
(EN) The present invention relates to a composition for treating gout, containing Angelica gigas extract, which is effective in treating gout by inhibiting xanthine oxidase and thus reducing uric acid in the blood or urine. Also, the present invention relates to a composition for preventing inflammation, containing Angelica gigas extract, which is effective in inhibiting the inflammation-inducing enzyme Cox-2. The Angelica gigas extract of the present invention is a liquid concentrate containing 98 wt % or more of decursin and decursinol angelate as main ingredients. The Angelica gigas extract of the present invention is extracted using only water and ethanol as a solvent to administer the extract to a human, and extracted by a purifying method using a difference between the temperature and the solubility to improve the purity thereof.
(FR) La présente invention concerne une composition pour traiter la goutte, contenant un extrait d'Angelica gigas, ayant pour effet d'inhiber la xanthine oxydase et donc de réduire l'acide urique dans le sang ou l'urine. La présente invention concerne en outre une composition destinée à prévenir les inflammations, contenant un extrait d'Angelica gigas, qui est efficace pour inhiber l'enzyme Cox-2 à l'origine des inflammations. L'extrait d'Angelica gigas de la présente invention est un concentré liquide contenant 98 % en poids ou plus de décursine et d'angélate de décursinol en tant qu'ingrédients principaux. L'extrait d'Angelica gigas de la présente invention est extrait en utilisant, comme solvant, seulement de l'eau et de l'éthanol pour qu'il puisse être administré un humain, et la pureté de l'extrait est améliorée en étant soumis à un procédé de purification basé sur une différence entre la température et la solubilité.
(KO) 본 발명은 잔틴 산화효소(xanthine oxidase) 저해를 통해 혈중 또는 뇨중의 요산을 감소시켜 통풍치료에 효과를 갖는 참당귀 추출물을 포함하는 통풍 치료용 조성물에 관한 것이다. 또한 본 발명은 염증유발효소 Cox-2를 저해하는 효과를 갖는 참당귀 추출물을 포함하는 통풍에서의 염증 예방용 조성물에 관한 것이다. 본 발명의 참당귀 추출물은 그 주성분인 데커신과 데커시놀 안젤레이트가 98 중량% 이상으로 구성된 액체 농축물로서, 인간에게 투여하기 위해 추출용매로 물과 에탄올만으로 추출하였고, 또한 순도를 높이기 위해 온도와 용해도 차이를 이용한 정제방법을 사용한 것이다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)
Also published as:
JP2012513458US20110262567CN102264377