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1. (WO2010074387) AZA-BICYCLO[2.2.1] HEPTENE DERIVATIVES, PREPARATION METHOD THEREOF, AND METHOD FOR PREPARING OSELTAMIVIR INTERMEDIATES USING THE SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/074387 International Application No.: PCT/KR2009/004948
Publication Date: 01.07.2010 International Filing Date: 02.09.2009
IPC:
C07D 451/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
451
Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02
containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane; Cyclic acetals thereof
04
with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring system
06
Oxygen atoms
Applicants:
(주)팜스웰바이오 PHARMSWELLBIO CO., LTD. [KR/KR]; 서울시 서초구 양재동 82-3 팜스웰빌딩 Pharmswell building 82-3 Yangjae-dong Seocho-gu Seoul 137-130, KR (AllExceptUS)
오세한 OH, Se Han [KR/KR]; KR (UsOnly)
김신종 KIM, Shin Jong [KR/KR]; KR (UsOnly)
이승종 LEE, Seung Jong [KR/KR]; KR (UsOnly)
최선애 CHOI, Sun Ae [KR/KR]; KR (UsOnly)
이용준 LEE, Yong Jun [KR/KR]; KR (UsOnly)
김학원 KIM, Hak-won [KR/KR]; KR (UsOnly)
이선화 LEE, Sun-hwa [KR/KR]; KR (UsOnly)
Inventors:
오세한 OH, Se Han; KR
김신종 KIM, Shin Jong; KR
이승종 LEE, Seung Jong; KR
최선애 CHOI, Sun Ae; KR
이용준 LEE, Yong Jun; KR
김학원 KIM, Hak-won; KR
이선화 LEE, Sun-hwa; KR
Agent:
이원희 LEE, Won-Hee; 서울시 강남구 역삼동 642-16 성지하이츠 2차 8층 8th Fl. Sung-ji Heights II 642-16 Yoksam-dong Kangnam-ku Seoul 135-080, KR
Priority Data:
10-2008-013084722.12.2008KR
Title (EN) AZA-BICYCLO[2.2.1] HEPTENE DERIVATIVES, PREPARATION METHOD THEREOF, AND METHOD FOR PREPARING OSELTAMIVIR INTERMEDIATES USING THE SAME
(FR) DÉRIVÉS D'AZA-BICYCLO[2.2.1]HEPTÈNE, LEURS MÉTHODES DE SYNTHÈSE, ET MÉTHODES DE SYNTHÈSE D'INTERMÉDIAIRES DE L'OSELTAMIVIR LES UTILISANT
(KO) 아자-바이사이클로[2.2.1]헵텐 유도체, 이의 제조방법 및 이를 이용한 오셀타미비르의 중간체의 제조방법
Abstract:
(EN) The present invention relates to aza-bicyclo[2.2.1] heptene derivatives, a preparation method thereof, and a method for preparing Oseltamivir intermediates using the same. The aza-bicyclo[2.2.1] heptene derivatives of chemical formula 1 and prepared by the present invention: are valuable as raw materials for Oseltamivir; remarkably reduce processes for preparing the existing Oseltamivir; enable preparation of the Oseltamivir at low cost by using low-priced compounds widely used in industry instead of high-priced raw materials. Furthermore, the derivatives prevent generation of explosive materials during synthesis thereof, thereby enabling safe and economical preparation of the Oseltamivir.
(FR) La présente invention concerne des dérivés d'aza-bicyclo[2.2.1]heptène, l'une de leurs méthodes de synthèse, ainsi qu'une méthode de synthèse d'intermédiaires d'Oseltamivir les utilisant. Les dérivés d'aza-bicyclo[2.2.1]heptène de formule chimique 1 synthétisés selon la présente invention : sont des produits de départ intéressants pour la synthèse de l'Oseltamivir; réduisent de façon remarquable le nombre d'étapes nécessaires à la synthèse d'Oseltamivir existante; permettent de synthétiser l'Oseltamivir de façon économique à partir de composés peu onéreux largement utilisés dans l'industrie au lieu de produits de départ onéreux. En outre, les dérivés empêchent la génération de substances explosives pendant la synthèse, ce qui permet une synthèse sûre et économique de l'Oseltamivir.
(KO) 본 발명은 아자-바이사이클로[2.2.1]헵텐 유도체, 이의 제조방법 및 이를 이용한 오셀타미비르의 중간체의 제조방법에 관한 것으로서, 본 발명에 의하여 제조되는 화학식 1로 표시되는 아자-바이사이클로[2.2.1]헵텐 유도체는 오셀타미비르의 원료물질로서 유용하게 사용될 수 있으며, 종래 오셀타미비르의 제조단계를 획기적으로 감소시킬 수 있고, 고가의 원료가 아닌 산업적으로 많이 사용되는 저가의 화합물을 사용하므로 경제적으로 오셀타미비르를 제조할 수 있으며, 나아가 합성과정에서 폭발의 위험이 있는 물질이 생성되지 않아 산업적으로 안전하고 경제적으로 오셀타미비르를 제조할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)