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1. (WO2010074380) PREPARATION METHOD OF POLYMERIC MICELLAR NANOPARTICLES COMPOSITION CONTAINING A POORLY WATER-SOLUBLE DRUG
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/074380 International Application No.: PCT/KR2009/003522
Publication Date: 01.07.2010 International Filing Date: 29.06.2009
IPC:
A61K 9/127 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
Applicants:
SAMYANG CORPORATION [KR/KR]; 263 Yeongi-dong, Jongno-gu Seoul 110-470, KR (AllExceptUS)
SEO, Min Hyo [KR/KR]; KR (UsOnly)
LEE, Sa Won [KR/KR]; KR (UsOnly)
Inventors:
SEO, Min Hyo; KR
LEE, Sa Won; KR
Agent:
KIM, Sun-young; Korea Coal Center, 10th Floor, 80-6 Susong-Dong, Chongro-Ku Seoul 110-727, KR
Priority Data:
10-2008-013453926.12.2008KR
Title (EN) PREPARATION METHOD OF POLYMERIC MICELLAR NANOPARTICLES COMPOSITION CONTAINING A POORLY WATER-SOLUBLE DRUG
(FR) MÉTHODE DE PRÉPARATION D'UNE COMPOSITION DE NANOPARTICULES MICELLAIRES POLYMÈRES CONTENANT UN MÉDICAMENT DIFFICILEMENT SOLUBLE DANS L'EAU
Abstract:
(EN) Provided is a method for preparing a poorly water-soluble drug-containing polymeric micellar nanoparticle composition, which includes: dissolving a poorly water-soluble drug, a salt of polylactic acid or polylactic acid derivative, whose carboxylic acid end is bound to an alkali metal ion, and an amphiphilic block copolymer into an organic solvent; and adding an aqueous solution to the resultant mixture in the organic solvent to form micelles, wherein the method requires no separate operation to remove the organic solvent prior to the formation of micelles. The method for preparing a poorly water-soluble drug-containing polymeric micellar nanoparticle composition is simple, reduces the processing time, and is amenable to mass production.
(FR) Cette invention concerne une méthode de préparation d'une composition de nanoparticules micellaires polymères contenant un médicament difficilement soluble dans l'eau, ladite méthode consistant à : dissoudre un médicament difficilement soluble dans l'eau, un sel d'acide polylactique ou un dérivé d'acide polylactique, l'extrémité acide carboxylique étant liée à un ion de métal alcalin, et un copolymère séquencé amphiphile dans un solvant organique ; et à ajouter une solution aqueuse au mélange résultant dans le solvant organique pour former des micelles, la méthode ne nécessitant aucune opération distincte pour éliminer le solvant organique avant la formation des micelles. La méthode de préparation de la composition de nanoparticules micellaires polymères contenant un médicament difficilement soluble dans l'eau est simple, elle réduit la durée de traitement et convient pour une production en masse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2011/006537EP2376062JP2012513985US20110257253CN102264350CA2746985
MX2011006537US20150359777NZ593735AU2009331027