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1. (WO2010074089) INDANYL COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/074089 International Application No.: PCT/JP2009/071339
Publication Date: 01.07.2010 International Filing Date: 22.12.2009
IPC:
C07C 217/28 (2006.01) ,A61K 31/195 (2006.01) ,A61K 31/216 (2006.01) ,A61K 31/41 (2006.01) ,A61P 1/02 (2006.01) ,A61P 3/14 (2006.01) ,A61P 5/18 (2006.01) ,A61P 19/02 (2006.01) ,A61P 19/08 (2006.01) ,A61P 19/10 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01) ,C07D 257/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
217
Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02
having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04
the carbon skeleton being acyclic and saturated
28
having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
216
of acids having aromatic rings, e.g. benactizyne, clofibrate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
02
Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
12
for electrolyte homeostasis
14
for calcium homeostasis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
18
of the parathyroid hormones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
10
for osteoporosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
257
Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02
not condensed with other rings
04
Five-membered rings
Applicants:
第一三共株式会社 DAIICHI SANKYO COMPANY,LIMITED [JP/JP]; 東京都中央区日本橋本町三丁目5番1号 3-5-1,Nihonbashi Honcho,Chuo-ku, Tokyo 1038426, JP (AllExceptUS)
中尾 彰 NAKAO, Akira; null (UsOnly)
五反田 建徳 GOTANDA, Kentoku; null (UsOnly)
青木 一真 AOKI, Kazumasa; null (UsOnly)
平野 慎平 HIRANO, Shimpei; null (UsOnly)
昼間 由晴 HIRUMA, Yoshiharu; null (UsOnly)
椎木 剛史 SHIIKI, Takeshi; null (UsOnly)
Inventors:
中尾 彰 NAKAO, Akira; null
五反田 建徳 GOTANDA, Kentoku; null
青木 一真 AOKI, Kazumasa; null
平野 慎平 HIRANO, Shimpei; null
昼間 由晴 HIRUMA, Yoshiharu; null
椎木 剛史 SHIIKI, Takeshi; null
Agent:
石橋 公樹 ISHIBASHI Koki; 東京都江戸川区北葛西一丁目16番13号 第一三共株式会社内 c/o DAIICHI SANKYO COMPANY, LIMITED, 1-16-13,Kitakasai, Edogawa-ku, Tokyo 1340081, JP
Priority Data:
2008-32747724.12.2008JP
Title (EN) INDANYL COMPOUNDS
(FR) COMPOSÉS INDANYLE
(JA) インダニル化合物
Abstract:
(EN) Provided are novel low-molecular compounds which exhibit calcium receptor antagonist activity, and which are highly safe and orally administrable, namely, compounds having general formula (I) or pharmacologically acceptable salts thereof.  In the general formula, A represents a single bond or the like; D represents a single bond or the like; R2a and R2b are the same or different from each other and represent a hydrogen atom, a halogen atom, or the like; R3a and R3b are the same or different from each other and represent a hydrogen atom, a halogen atom, or the like; R4 and R5 are the same or different from each other and represent a hydrogen atom, a halogen atom, or the like; R6 represents methyl, ethyl, or the like; m represents an integer of 0 to 6, or the like; and Z represents carboxyl or the like.
(FR) L'invention concerne de nouveaux composés de faible poids moléculaire qui présentent une activité antagoniste des récepteurs calciques, et qui sont extrêmement sûrs et peuvent être administrés par voie orale, à savoir les composés ayant la formule générale (I) ou leurs sels pharmacologiquement acceptables. Dans la formule générale, A représente une simple liaison ou un élément similaire, D représente une simple liaison ou un élément similaire, R2a et R2b sont identiques ou différents l'un de l'autre et représentent un atome d'hydrogène, un atome d'halogène ou un groupe similaire, R3a et R3b sont identiques ou différents l'un de l'autre et représentent un atome d'hydrogène, un atome d'halogène ou un groupe similaire, R4 et R5 sont identiques ou différents l'un de l'autre et représentent un atome d'hydrogène, un atome d'halogène ou un groupe similaire, R6 représente un groupe méthyle, éthyle, ou un groupe similaire, m représente un nombre entier de 0 à 6 ou un nombre similaire, et Z représente un groupe carboxyle ou un groupe similaire.
(JA) 課題は、カルシウム受容体拮抗作用を示し、かつ安全性が高く経口投与が可能な新規な低分子化合物を提供することである。 解決手段は、一般式(I)を有する化合物又はその薬理上許容される塩である。 [式中、各置換基は以下のように定義される。 A:単結合等;D:単結合等;R2a及びR2b:それぞれ同一又は異なって、水素原子又はハロゲン原子等;R3a及びR3b:それぞれ同一又は異なって、水素原子又はハロゲン原子等;R及びR:それぞれ同一又は異なって、水素原子、ハロゲン原子等; R:メチル基、エチル基等;m:0-6の整数等;Z:カルボキシ基等]
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
IL213736MXMX/a/2011/006656EP2374788SG172141JPWO2010074089US20110319359
CN102307847RU0002474572CA2748250ES2412408MX2011006656CO6341613
KR1020110106312NZ593676AU2009331253VN28043ID2012/00607MYPI 2011002738
IN1353/MUMNP/2011BRPI0922503