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1. (WO2010074088) CYCLIC AMINE COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/074088 International Application No.: PCT/JP2009/071338
Publication Date: 01.07.2010 International Filing Date: 22.12.2009
IPC:
C07D 205/04 (2006.01) ,A61K 31/397 (2006.01) ,A61K 31/40 (2006.01) ,A61K 31/41 (2006.01) ,A61P 1/02 (2006.01) ,A61P 3/14 (2006.01) ,A61P 5/18 (2006.01) ,A61P 19/00 (2006.01) ,A61P 19/02 (2006.01) ,A61P 19/10 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01) ,C07D 207/08 (2006.01) ,C07D 207/10 (2006.01) ,C07D 207/12 (2006.01) ,C07D 403/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
205
Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
397
having four-membered rings, e.g. azetidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
02
Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
12
for electrolyte homeostasis
14
for calcium homeostasis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
18
of the parathyroid hormones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
10
for osteoporosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
08
with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
12
Oxygen or sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
第一三共株式会社 DAIICHI SANKYO COMPANY,LIMITED [JP/JP]; 東京都中央区日本橋本町三丁目5番1号 3-5-1,Nihonbashi Honcho,Chuo-ku, Tokyo 1038426, JP (AllExceptUS)
中尾 彰 NAKAO, Akira; null (UsOnly)
五反田 建徳 GOTANDA, Kentoku; null (UsOnly)
青木 一真 AOKI, Kazumasa; null (UsOnly)
平野 慎平 HIRANO, Shimpei; null (UsOnly)
昼間 由晴 HIRUMA, Yoshiharu; null (UsOnly)
椎木 剛史 SHIIKI, Takeshi; null (UsOnly)
Inventors:
中尾 彰 NAKAO, Akira; null
五反田 建徳 GOTANDA, Kentoku; null
青木 一真 AOKI, Kazumasa; null
平野 慎平 HIRANO, Shimpei; null
昼間 由晴 HIRUMA, Yoshiharu; null
椎木 剛史 SHIIKI, Takeshi; null
Agent:
石橋 公樹 ISHIBASHI Koki; 東京都江戸川区北葛西一丁目16番13号 第一三共株式会社内 c/o DAIICHI SANKYO COMPANY, LIMITED, 1-16-13,Kitakasai, Edogawa-ku, Tokyo 1340081, JP
Priority Data:
2008-32747624.12.2008JP
Title (EN) CYCLIC AMINE COMPOUNDS
(FR) COMPOSÉS AMINE CYCLIQUES
(JA) 環状アミン化合物
Abstract:
(EN) Provided are novel low-molecular compounds which exhibit calcium receptor antagonist activity, and which are highly safe and orally administrable, namely, compounds having general formula (I) or pharmacologically acceptable salts thereof.  In the general formula, R1, R2a, and R2b are each a hydrogen atom or the like; R3 is methyl, ethyl, or the like; Z is carboxyl or the like; Ar is phenyl or the like; A is a single bond or the like; B is a single bond or the like; n is 0 or 1; and m is an integer of 0 to 6.
(FR) L'invention concerne des nouveaux composés de faible poids moléculaire qui présentent une activité antagoniste des récepteurs calciques, et qui sont extrêmement sûrs et peuvent être administrés par voie orale, à savoir les composés ayant la formule générale (I) ou leurs sels pharmacologiquement acceptables. Dans la formule générale, R1, R2a, et R2b représentent chacun un atome d'hydrogène ou un groupe similaire, R3 représente un groupe méthyle, éthyle, ou un groupe similaire, Z représente un groupe carboxyle ou un groupe similaire, Ar représente un groupe phényle ou un groupe similaire, A représente une simple liaison ou un élément similaire, B représente une simple liaison ou un élément similaire, n vaut 0 ou 1, et m est un nombre entier de 0 à 6.
(JA) 課題は、カルシウム受容体アンタゴニスト作用を示し、かつ安全性が高く経口投与が可能な新規な低分子化合物を提供することである。 解決手段は、一般式(I)を有する化合物又はその薬理上許容される塩である。 [式中、各置換基は以下のように定義される。R及びR2a,R2b:水素原子等。R:メチル基、エチル基等。Z:カルボキシ基等。Ar:フェニル基等。A:単結合等。B:単結合等。n:0又は1。m:0-6の整数。]
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
IL213697MXMX/a/2011/006655EP2374794SG172140US20110319468CN102307852
RU2011130928RU0002478616CA2748249MX2011006655KR1020110096547NZ593675
AU2009331252VN27588ID051.3926MYPI 2011002737IN1351/MUMNP/2011BRPI0923654