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1. (WO2010074082) MODIFIED VASOHIBIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/074082 International Application No.: PCT/JP2009/071328
Publication Date: 01.07.2010 International Filing Date: 22.12.2009
IPC:
C07K 14/52 (2006.01) ,A61K 38/00 (2006.01) ,A61K 47/34 (2006.01) ,A61K 47/48 (2006.01) ,A61P 35/00 (2006.01) ,C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
塩野義製薬株式会社 Shionogi & Co., Ltd. [JP/JP]; 大阪府大阪市中央区道修町三丁目1番8号 1-8, Doshomachi 3-chome, Chuo-ku, Osaka-shi, Osaka 5410045, JP (AllExceptUS)
国立大学法人東北大学 TOHOKU UNIVERSITY [JP/JP]; 宮城県仙台市青葉区片平二丁目1番1号 2-1-1 Katahira, Aoba-ku, Sendai-shi Miyagi 9808577, JP (AllExceptUS)
佐藤 靖史 SATO, Yasufumi; null (UsOnly)
中村 巧 NAKAMURA, Takumi; null (UsOnly)
松本 光史 MATSUMOTO, Mitsunobu; null (UsOnly)
佐藤 公昭 SATO, Masaaki; null (UsOnly)
北条 完二 HOJO, Kanji; null (UsOnly)
Inventors:
佐藤 靖史 SATO, Yasufumi; null
中村 巧 NAKAMURA, Takumi; null
松本 光史 MATSUMOTO, Mitsunobu; null
佐藤 公昭 SATO, Masaaki; null
北条 完二 HOJO, Kanji; null
Agent:
細田 芳徳 HOSODA, Yoshinori; 大阪府大阪市中央区大手前一丁目7番31号 OMMビル5階 私書箱26号 細田国際特許事務所内 c/o Hosoda International Patent Office, P.O. Box 26, OMM Building 5th Floor, 7-31, Otemae 1-chome, Chuo-ku, Osaka-shi, Osaka 5406591, JP
Priority Data:
2008-32840624.12.2008JP
Title (EN) MODIFIED VASOHIBIN
(FR) VASOHIBINE MODIFIÉE
(JA) バソヒビン修飾体
Abstract:
(EN) A modified vasohibin bearing polyethylene glycol bonded thereto, which satisfies the requirements: (1) the solubility (25°C, pH7.4) is 1mg/mL or above and (2) an anti-angiogenic activity is exerted.  The modified vasohibin exhibits a high solubility at a pH around neutrality, and is therefore suitable for use in treating diseases of which the treatment necessitates anti-angiogenic effect.
(FR) L'invention porte sur un polyéthylène glycol portant une vasohibine modifiée liée à celui-ci, qui satisfait les exigences suivantes : (1) la solubilité (25°C, pH 7,4) est de 1 mg/mL ou plus et (2) une activité antiangiogénique est exercée. La vasohibine modifiée présente une solubilité élevée à un pH voisin de la neutralité, et est par conséquent appropriée pour une utilisation dans le traitement de maladies dont le traitement nécessite un effet antiangiogénique.
(JA)  (1)pH7.4における溶解度(25℃)が1mg/mL以上である、及び(2)血管新生抑制作用を有する、を満たすポリエチレングリコールが結合してなるバソヒビン修飾体。本発明のバソヒビン修飾体は、中性付近における溶解性が高いことから、血管新生抑制効果を要する疾患の治療等に好適に用いられる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
JPWO2010074082