Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2010073647) HUMAN ANTI-HUMAN INFLUENZA VIRUS ANTIBODY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/073647 International Application No.: PCT/JP2009/007159
Publication Date: 01.07.2010 International Filing Date: 24.12.2009
IPC:
C12N 15/00 (2006.01) ,A61K 39/395 (2006.01) ,A61P 31/16 (2006.01) ,C07K 16/10 (2006.01) ,C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
16
for influenza or rhinoviruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08
against material from viruses
10
from RNA viruses
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
国立大学法人大阪大学 OSAKA UNIVERSITY [JP/JP]; 大阪府吹田市山田丘1番1号 1-1, Yamadaoka, Suita-shi, Osaka 5650871, JP (AllExceptUS)
一般財団法人阪大微生物病研究会 THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY [JP/JP]; 大阪府吹田市山田丘3番1号大阪大学内 c/o OSAKA UNIVERSITY, 3-1, Yamadaoka, Suita-shi, Osaka 5650871, JP (AllExceptUS)
株式会社ベネシス Benesis Corporation [JP/JP]; 大阪府大阪市中央区北浜二丁目6番18号 2-6-18, Kitahama, Chuo-ku, Osaka-shi, Osaka 5418505, JP (AllExceptUS)
株式会社医学生物学研究所 MEDICAL AND BIOLOGICAL LABORATORIES CO., LTD [JP/JP]; 愛知県名古屋市中区栄四丁目5番3号 4-5-3, Sakae, Naka-ku, Nagoya-shi, Aichi 4600008, JP (AllExceptUS)
生田和良 IKUTA, Kazuyoshi [JP/JP]; JP (UsOnly)
纐纈律子 KOKETSU, Ritsuko [JP/JP]; JP (UsOnly)
奥野良信 OKUNO, Yoshinobu [JP/JP]; JP (UsOnly)
柚木幹弘 YUNOKI, Mikihiro [JP/JP]; JP (UsOnly)
井手野祥次 IDENO, Shoji [JP/JP]; JP (UsOnly)
大下昌利 OSHITA, Masatoshi [JP/JP]; JP (UsOnly)
久原基樹 KUHARA, Motoki [JP/JP]; JP (UsOnly)
百田匡寿 MOMOTA, Masatoshi [JP/JP]; JP (UsOnly)
Inventors:
生田和良 IKUTA, Kazuyoshi; JP
纐纈律子 KOKETSU, Ritsuko; JP
奥野良信 OKUNO, Yoshinobu; JP
柚木幹弘 YUNOKI, Mikihiro; JP
井手野祥次 IDENO, Shoji; JP
大下昌利 OSHITA, Masatoshi; JP
久原基樹 KUHARA, Motoki; JP
百田匡寿 MOMOTA, Masatoshi; JP
Agent:
庄司隆 SHOJI, Takashi; 東京都中央区東日本橋3-4-1 秋場ビル6階 6F, Akiba Bldg.,3-4-1, Higashi-nihonbashi, Chuo-ku, Tokyo 1030004, JP
Priority Data:
2008-33042525.12.2008JP
2009-14683219.06.2009JP
Title (EN) HUMAN ANTI-HUMAN INFLUENZA VIRUS ANTIBODY
(FR) ANTICORPS HUMAIN ANTI-VIRUS DE LA GRIPPE HUMAINE
(JA) 抗ヒトインフルエンザウイルス・ヒト型抗体
Abstract:
(EN) Disclosed is a human antibody having a neutralization activity against a human influenza virus. Specifically disclosed is a human antibody which can recognize a highly conserved region in a human influenza A virus subtype H3N2 and a human influenza B virus and has a neutralization activity against the virus. More specifically disclosed is a human anti-human influenza virus antibody which has a neutralization activity against a human influenza A virus subtype H3N2 and is capable of binding to a hemagglutinin HA1 domain in a human influenza A virus subtype H3N2 or which has a neutralization activity against a human influenza B virus, wherein the nucleotide sequence of DNA that encodes a variable region of the antibody comprises any one sequence selected from those depicted in SEQ ID NO:5 to SEQ ID NO:12.
(FR) L'invention porte sur un anticorps humain ayant une activité de neutralisation contre un virus de la grippe humaine. L'invention porte spécifiquement sur un anticorps humain qui peut reconnaître une région hautement conservée dans un sous-type H3N2 du virus de la grippe A humaine et un virus de la grippe B humaine et a une activité de neutralisation contre le virus. L'invention porte plus spécifiquement sur un anticorps humain anti-virus de la grippe humaine qui a une activité de neutralisation contre un sous-type H3N2 du virus de la grippe A humaine et est capable de se lier à un domaine d'hémaglutinine HA1 dans un sous-type H3N2 du virus de la grippe A humaine ou qui a une activité de neutralisation contre un virus de la grippe B humaine, la séquence nucléotidique d'ADN qui code pour une région variable de l'anticorps comprenant l'une quelconque des séquences choisies parmi celles décrites dans SEQ ID NO : 5 à SEQ ID NO : 12.
(JA) 本発明は、ヒトインフルエンザウイルスに対して中和活性を有するヒト型抗体に関する。より詳しくは、ヒトインフルエンザA型ウイルスのH3N2サブタイプ又はヒトインフルエンザB型ウイルスに対して、高度に保存された領域を認識し、中和活性を有するヒト型抗体に関する。ヒトインフルエンザA型ウイルスH3N2サブタイプに対して中和活性を有し、ヒトインフルエンザA型ウイルスH3N2サブタイプのヘマグルチニンHA1領域に結合する、又は、ヒトインフルエンザB型ウイルスに対して中和活性を有する、抗ヒトインフルエンザウイルス・ヒト型抗体であり、抗体の可変領域をコードするDNAの塩基配列が、配列番号5~12に示すいずれかの配列を含む抗体による。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP2380976JPWO2010073647US20110319600CN102264896