Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2010073544) METHOD FOR TESTING RISK OF CORONARY ARTERY DISEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/073544 International Application No.: PCT/JP2009/006918
Publication Date: 01.07.2010 International Filing Date: 16.12.2009
Chapter 2 Demand Filed: 05.10.2010
IPC:
C12N 15/09 (2006.01) ,A61K 45/00 (2006.01) ,A61P 9/00 (2006.01) ,A61P 9/10 (2006.01) ,A61P 43/00 (2006.01) ,C12N 1/15 (2006.01) ,C12N 1/19 (2006.01) ,C12N 1/21 (2006.01) ,C12N 5/10 (2006.01) ,C12Q 1/02 (2006.01) ,C12Q 1/68 (2006.01) ,G01N 33/15 (2006.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
15
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
16
Yeasts; Culture media therefor
19
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
21
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15
Medicinal preparations
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
国立大学法人 東京医科歯科大学 NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY [JP/JP]; 東京都文京区湯島一丁目5番45号 5-45, Yushima 1-chome, Bunkyo-ku, Tokyo 1138510, JP (AllExceptUS)
学校法人北里研究所 SCHOOL JURIDICAL PERSON KITASATO INSTITUTE [JP/JP]; 東京都港区白金5丁目9番1号 9-1, Shirokane 5-chome,, Minato-ku, Tokyo 1088641, JP (AllExceptUS)
学校法人東海大学 TOKAI UNIVERSITY EDUCATIONAL SYSTEM [JP/JP]; 東京都渋谷区富ヶ谷2丁目28番4号 28-4, Tomigaya 2-chome, Shibuya-ku, Tokyo 1510063, JP (AllExceptUS)
国立大学法人三重大学 MIE UNIVERSITY [JP/JP]; 三重県津市栗真町屋町1577 1577, Kurimamachiya-cho, Tsu-shi, Mie 5148507, JP (AllExceptUS)
木村彰方 KIMURA, Akinori [JP/JP]; JP (UsOnly)
日野原邦彦 HINOHARA, Kunihiko [JP/JP]; JP (UsOnly)
中島敏晶 NAKAJIMIA, Toshiaki [JP/JP]; JP (UsOnly)
和泉徹 IZUMI, Tohru [JP/JP]; JP (UsOnly)
猪子英俊 INOKO, Hidetoshi [JP/JP]; JP (UsOnly)
山田芳司 YAMADA, Yoshiji [JP/JP]; JP (UsOnly)
Inventors:
木村彰方 KIMURA, Akinori; JP
日野原邦彦 HINOHARA, Kunihiko; JP
中島敏晶 NAKAJIMIA, Toshiaki; JP
和泉徹 IZUMI, Tohru; JP
猪子英俊 INOKO, Hidetoshi; JP
山田芳司 YAMADA, Yoshiji; JP
Agent:
南条雅裕 NANJO, Masahiro; 東京都港区赤坂9-7-1416  東京ACTi国際特許事務所 TOKYO ACTi International Patent Office, 9-7-2-1416, Akasaka Minato-ku, Tokyo 1070052, JP
Priority Data:
2008-32796024.12.2008JP
Title (EN) METHOD FOR TESTING RISK OF CORONARY ARTERY DISEASES
(FR) MÉTHODE DE DÉTERMINATION DU RISQUE DE MALADIES CORONARIENNES
(JA) 冠状動脈疾患リスクの検査方法
Abstract:
(EN) Disclosed are: a method for testing for coronary artery diseases utilizing an SNP of which the correlation with the diseases has been fully demonstrated or the like; a reagent for use in the method; and others. Specifically disclosed is a method for testing the risk of coronary artery diseases in a patient, which comprises a step of detecting a mutation that causes the increase in the expression level of MKL1 gene or the occurrence of increase in the expression level of MKL1 gene in a sample collected from the subject.
(FR) La présente invention concerne : une méthode de détermination des maladies coronariennes utilisant un SNP dont la corrélation aux pathologies a été entièrement démontrée, etc.; un réactif utilisable dans la méthode; etc. La présente invention concerne spécifiquement une méthode de détermination du risque de maladies coronariennes chez un patient, ladite méthode comprenant une étape de détection d'une mutation qui provoque l'augmentation du niveau d'expression du gène MKL1 ou la fréquence augmentation du niveau d'expression d'un gène MKL1 dans un échantillon récolté chez le sujet.
(JA)  本発明は、疾患との関連が十分に検証されたSNP等を利用する冠状動脈疾患の検査方法、当該方法に用いられる試薬等を提供することを目的とする。 本発明は、被検者の冠状動脈疾患リスクの検査方法であって、被験者から採取した試料におけるMKL1遺伝子発現を亢進させる変異又はMKL1遺伝子発現の亢進を検出する工程を含む方法を提供するものである。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)