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1. (WO2010073326) PERCUTANEOUS ABSORPTION PREPARATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/073326 International Application No.: PCT/JP2008/073487
Publication Date: 01.07.2010 International Filing Date: 24.12.2008
IPC:
A61K 47/32 (2006.01) ,A61K 9/70 (2006.01) ,A61K 31/18 (2006.01) ,A61K 47/04 (2006.01) ,A61K 47/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
32
Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
18
Sulfonamides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
04
Non-metals; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
14
Esters of carboxylic acids
Applicants:
ニチバン株式会社 NICHIBAN CO., LTD. [JP/JP]; 〒1128663 東京都文京区関口二丁目3番3号 Tokyo 3-3, Sekiguchi 2-chome, Bunkyo-ku, Tokyo 1128663, JP (AllExceptUS)
川原 康慈 KAWAHARA, Koji [JP/JP]; JP (UsOnly)
古賀 徹 KOGA, Toru [JP/JP]; JP (UsOnly)
八巻 春奈 YAMAKI, Haruna [JP/JP]; JP (UsOnly)
林 亨子 HAYASHI, Kyoko [JP/JP]; JP (UsOnly)
Inventors:
川原 康慈 KAWAHARA, Koji; JP
古賀 徹 KOGA, Toru; JP
八巻 春奈 YAMAKI, Haruna; JP
林 亨子 HAYASHI, Kyoko; JP
Agent:
萼 経夫 HANABUSA, Tsuneo; 〒1010062 東京都千代田区神田駿河台3丁目2番地 新御茶ノ水アーバントリニティ 萼特許事務所内 Tokyo c/o Hanabusa Patent Office, Shin-Ochanomizu Urban Trinity, 2, Kandasurugadai 3-chome, Chiyoda-ku Tokyo 1010062, JP
Priority Data:
Title (EN) PERCUTANEOUS ABSORPTION PREPARATION
(FR) PRÉPARATION À ABSORPTION PERCUTANÉE
(JA) 経皮吸収型製剤
Abstract:
(EN) Provided is a percutaneous absorption preparation comprising a support having provided thereon an adhesive layer. An adhesive composition for forming the adhesive layer contains an adhesive mainly composed of an acrylic adhesive formed of a resin obtained by polymerization using an acrylic ester and/or a methacrylic ester having no carboxyl group in the molecule as a main monomer, a basic drug, silica particles and a polyhydric alcohol fatty acid ester. The polyhydric alcohol fatty acid ester is contained in an amount of from 15 to 40% by mass of the total mass of the adhesive composition. The percutaneous absorption preparation enables the addition of a permeation accelerator in a large amount without decreasing a cohesive force of the adhesive and also satisfies basic performance required for a percutaneous absorption preparation such that drug bioavailability is increased and the adhesive remaining on the skin or being sticky on the skin is improved.
(FR) L'invention porte sur une préparation à absorption percutanée comportant un support revêtu d'une couche adhésive. La composition adhésive formant ladite couche contient un adhésif principalement constitué par: un adhésif acrylique comprenant une résine obtenue par polymérisation d'un ester acrylique ou méthacrylique sans groupe carboxyle dans sa molécule et constituant le monomère principal, un médicament de base, des particules de silice, et un ester d'acide gras et d'alcool polyhydrique formant de 15 à 40% de la masse totale de la composition adhésive. Ladite préparation permet l'adjonction d'un accélérateur de perméation en quantité importante sans réduire la force cohésive de l'adhésif, tout en satisfaisant aux performances de base requises d'une telle préparation. La biodisponibilité s'en trouve accrue et l'adhésif demeurant sur la peau ou y collant est amélioré.
(JA) 支持体に粘着剤層を設けてなる経皮吸収型製剤において、該粘着剤層を形成する粘着剤組成物が、主モノマーとして分子内にカルボキシル基を持たないアクリル酸エステル及び/又はメタクリル酸エステルを用い、重合してなる樹脂からなるアクリル系粘着剤を主とする粘着剤、塩基性薬物、シリカ粒子、並びに多価アルコール脂肪酸エステルを含有し、前記多価アルコール脂肪酸エステルは粘着剤組成物の全質量に対して15~40質量%の割合で含まれてなる、経皮吸収型製剤であって、粘着剤の凝集力を低下させることなく透過促進剤の多量添加を可能にし、また、薬物の生物学的利用能を向上させ、且つ粘着剤の皮膚への残留や皮膚のべたつきを改善するなどの経皮吸収型製剤として求められる基本性能をも満足する経皮吸収型製剤を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)