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1. (WO2010073258) BICYCLIC TRITERPENOID IRIPALLIDAL AS A NOVEL ANTIGLIOMA AND ANTINEOPLASTIC THERAPY IN VITRO
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/073258 International Application No.: PCT/IN2009/000336
Publication Date: 01.07.2010 International Filing Date: 11.06.2009
IPC:
C07C 403/00 (2006.01) ,A61K 31/122 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
403
Derivatives of cyclohexane or of a cyclohexene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene rings, e.g. vitamin A, beta-carotene, beta-ionone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
122
having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
Applicants:
DEPARTMENT OF BIOTECHNOLOGY [IN/IN]; Block 2, 7th Floor, CGO Complex Lodhi Road New Delhi 110 003, IN (AllExceptUS)
NATIONAL BRAIN RESEARCH CENTRE [IN/IN]; Nainwal Mode Manesar 122 050, IN (AllExceptUS)
SEN, Ellora [IN/IN]; IN (UsOnly)
KOUL, Nitin [IN/IN]; IN (UsOnly)
SHARMA, Vivek [IN/IN]; IN (UsOnly)
TEWARI, Richa [IN/IN]; IN (UsOnly)
Inventors:
SEN, Ellora; IN
KOUL, Nitin; IN
SHARMA, Vivek; IN
TEWARI, Richa; IN
Agent:
DAVAR, G.S.; L.S. Davar & Co. 32 Radha Madhav Dutta Garden Lane Kolkata 700 010, IN
Priority Data:
2915/DEL/0822.12.2008IN
Title (EN) BICYCLIC TRITERPENOID IRIPALLIDAL AS A NOVEL ANTIGLIOMA AND ANTINEOPLASTIC THERAPY IN VITRO
(FR) IRRIPALLIDAL TRIPERPÉNOÏDE BICYCLIQUE EN TANT QUE NOUVEAU TRAITEMENT ANTI-GLIOME ET ANTINÉOPLASIQUE IN VITRO
Abstract:
(EN) This invention relates to a Bicyclic triterpenoid Iripallidal as a novel anti- glioma and anti neoplastic agent in vitro, having the composition [(-) (6R, 1OS, 11S, 18R, 22S)-26 Hydroxy -22-α methylcyloirid- 16-enal NSC 631939], wherein it binds to Ras GRP3, a phorbol ester receptor that links DAG/phorbolester signaling with Ras activation and induces phosphorylation of ER Kl1/2 in a Ras dependent manner, reducing proliferation of cancer cell lines to the extent of 50-70%.
(FR) La présente invention porte sur un irripallidal triperpénoïde bicyclique en tant que nouveau traitement anti-gliome et antinéoplasique in vitro, présentant la composition suivante : [(-) (6R, 1OS, 11S, 18R, 22S)-26 hydroxy -22-α méthylcyloïrid- 16-énal NSC 631939], celui-ci se liant à Ras-GRP3, un récepteur d'ester de phorbol qui lie la signalisation DAG/ester de phorbol avec l'activation de Ras et induit la phosphorylation de Erk1/2 de manière Ras-dépendante, et réduit la prolifération des lignées de cellules cancéreuses de 50 à 70 %.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2367784US20110054040