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1. (WO2010073257) AN IMMUNODOMINANT B-CELL EPITOPE BASED PROTEIN VACCINE AGAINST ANTHRAX AND METHOD OF PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/073257 International Application No.: PCT/IN2009/000230
Publication Date: 01.07.2010 International Filing Date: 08.04.2009
IPC:
G06F 19/00 (2006.01) ,C07K 16/12 (2006.01) ,A61K 38/16 (2006.01) ,A61P 31/04 (2006.01)
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12
against material from bacteria
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
KAUR, Manpreet [IN/IN]; IN
CHUG, Hema [IN/IN]; IN
BHATNAGAR, Rakesh [IN/IN]; IN
Inventors:
KAUR, Manpreet; IN
CHUG, Hema; IN
BHATNAGAR, Rakesh; IN
Agent:
SUBRAMANIAM, Hariharan; Subramaniam, Nataraj & Associates E-556, Greater Kailash II New Delhi 110 048, IN
Priority Data:
2947/DEL/200826.12.2008IN
Title (EN) AN IMMUNODOMINANT B-CELL EPITOPE BASED PROTEIN VACCINE AGAINST ANTHRAX AND METHOD OF PREPARATION THEREOF
(FR) VACCIN PROTÉIQUE À BASE D'ÉPITOPES B IMMUNODOMINANTS CONTRE L'ANTHRAX ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ
Abstract:
(EN) The present invention relates to the development of immunodominant B-cell epitope based protein vaccine having SEQ ID No.: 1 eliciting immune response against anthrax. The invention also relates to a polynucleotide sequence having SEQ ID No.: 2 encoding epitope based protein vaccine. The invention also relates to the method of preparation and purification of epitope based protein vaccine. The present invention further relates to vaccine composition of B-cell epitope based protein vaccine against anthrax, its method of preparation and process of using the composition. The vaccine or the vaccine composition of the present invention generates high titers of antibodies having high affinity and avidity and are highly effective in in vitro neutralization of B. anthracis lethal toxin and conferring protection against in vivo lethal toxin challenge.
(FR) La présente invention concerne la mise au point d'un vaccin protéique à base d'épitopes B immunodominants de SEQ ID n° 1 élicitant une réponse immunitaire contre l'anthrax. L'invention concerne également une séquence polynucléotidique de SEQ ID n° 2 codant pour le vaccin protéique à base d'épitopes. L'invention concerne en outre le procédé de préparation et de purification du vaccin protéique à base d'épitopes. La présente invention concerne de plus une composition vaccinale de vaccin protéique à base d'épitopes B contre l'anthrax, son procédé de préparation et un processus d'utilisation de la composition. Le vaccin ou la composition vaccinale de la présente invention produit des titres élevés d'anticorps ayant une affinité et une avidité fortes et est extrêmement efficace pour neutraliser in vitro la toxine mortelle de B. anthracis et pour conférer une protection contre une provocation létale in vivo avec la toxine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)