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1. (WO2010073124) PROCESSES FOR PREPARING HIGHLY PURE ROTIGOTINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/073124 International Application No.: PCT/IB2009/007975
Publication Date: 01.07.2010 International Filing Date: 22.12.2009
IPC:
C07D 333/06 (2006.01) ,C07D 333/14 (2006.01) ,A61K 31/381 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
06
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
06
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
14
Radicals substituted by singly bound hetero atoms other than halogen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
38
having sulfur as a ring hetero atom
381
having five-membered rings
Applicants:
ACTAVIS GROUP PTC EHF [IS/IS]; Reykjavikurvegi 76-78 IS-220 Hafnarfj R Ur, IS (AllExceptUS)
KHUNT, Mayur, Devjibhai [IN/IN]; IN (UsOnly)
VARMA, Shrikant [IN/IN]; IN (UsOnly)
PATIL, Nilesh, Sudhir [IN/IN]; IN (UsOnly)
PAGIRE, Haushabhau, Shivaji [IN/IN]; IN (UsOnly)
PRADHAN, Nitin, Sharadchandra [IN/IN]; IN (UsOnly)
Inventors:
KHUNT, Mayur, Devjibhai; IN
VARMA, Shrikant; IN
PATIL, Nilesh, Sudhir; IN
PAGIRE, Haushabhau, Shivaji; IN
PRADHAN, Nitin, Sharadchandra; IN
Priority Data:
200/CHE/200929.01.2009IN
3286/CHE/200826.12.2008IN
Title (EN) PROCESSES FOR PREPARING HIGHLY PURE ROTIGOTINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
(FR) PROCÉDÉ DE PRÉPARATION DE ROTIGOTINE TRÈS PURE OU D'UN SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELLE-CI
Abstract:
(EN) Provided herein are convenient, industrially advantageous and environmentally friendly processes for the preparation of (-)-(S)-5-hydroxy-2-[N-n-propyl-N-2-(2-thienyl)ethylamino] tetralin (rotigotine) or a pharmaceutically acceptable salt thereof. Provided further herein is a highly pure rotigotine or a pharmaceutically acceptable salt thereof substantially free of impurities, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure rotigotine or a pharmaceutically acceptable salt thereof substantially free of impurities.
(FR) La présente invention concerne des procédés commodes, avantageux sur le plan industriel et qui respectent l'environnement, de préparation de (-)-(S)-5-hydroxy-2-[N-n-propyl-N-2-(2-thiényl)éthylamino] tétraline (rotigotine) ou d'un sel pharmaceutiquement acceptable de celle-ci. La présente invention concerne en outre une rotigotine très pure ou un sel pharmaceutiquement acceptable de celle-ci sensiblement dépourvu d'impuretés, des procédés de préparation associés, et des compositions pharmaceutiques qui comprennent une rotigotine très pure ou un sel pharmaceutiquement acceptable de celle-ci sensiblement dépourvu d'impuretés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20110313176