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1. (WO2010073012) HUMAN ANTI TSHR ANTIBODIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/073012 International Application No.: PCT/GB2009/002946
Publication Date: 01.07.2010 International Filing Date: 23.12.2009
IPC:
C07K 16/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
R S R LIMITED [GB/GB]; Avenue Park Pentwyn Cardiff CF23 8HE, GB (AllExceptUS)
REES SMITH, Bernard [GB/GB]; GB (UsOnly)
SANDERS, Jane [GB/GB]; GB (UsOnly)
FURMANIAK, Jadwiga [GB/GB]; GB (UsOnly)
Inventors:
REES SMITH, Bernard; GB
SANDERS, Jane; GB
FURMANIAK, Jadwiga; GB
Agent:
DEAN, John; Withers & Rogers LLP Goldings House 2 Hays Lane London SE1 2HW, GB
Priority Data:
0823562.424.12.2008GB
0908945.922.05.2009GB
Title (EN) HUMAN ANTI TSHR ANTIBODIES
(FR) ANTICORPS
Abstract:
(EN) According to one aspect there is provided An isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on TSHR constitutive activity wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR.
(FR) Dans l'un de ses aspects, la présente invention concerne une molécule d'anticorps humain isolée qui se lie au TSHR et réduit la stimulation induite par ligand du TSHR, sans avoir d'effet sur l'activité constitutive du TSHR, la molécule d'anticorps humain isolée présentant les caractéristiques d'inhibition de TSH et de liaison de M22 au TSHR des auto-anticorps de TSHR sériques du patient.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2367850JP2012513747US20110300138CN102264764EP2617734EP2617735
ES2540538IN3699/DELNP/2011