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1. (WO2010072843) USE OF A PEPTIDE DERIVED FROM ER-ALPHA FOR RESTORING SENSITIVITY TO ANTIESTROGENIC COMPOUNDS IN BREAST TUMOUR CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/072843 International Application No.: PCT/EP2009/067932
Publication Date: 01.07.2010 International Filing Date: 24.12.2009
IPC:
A61P 35/00 (2006.01) ,A61P 35/04 (2006.01) ,A61K 38/17 (2006.01) ,C07K 7/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
Applicants:
BIOINDUSTRY PARK SILVANO FUMERO S.p.A. [IT/IT]; Via Ribes, 5 Colleretto Giacosa, IT (AllExceptUS)
PANETTO, Arianna [IT/IT]; IT (UsOnly)
REINERI, Stefania [IT/IT]; IT (UsOnly)
CUTRUPI, Santina [IT/IT]; IT (UsOnly)
DE BORTOLI, Michele [IT/IT]; IT (UsOnly)
Inventors:
PANETTO, Arianna; IT
REINERI, Stefania; IT
CUTRUPI, Santina; IT
DE BORTOLI, Michele; IT
Agent:
JORIO, Paolo; STUDIO TORTA S.r.l. Via Viotti, 9 I-10121 Torino, IT
Priority Data:
TO2008A 00098924.12.2008IT
Title (EN) USE OF A PEPTIDE DERIVED FROM ER-ALPHA FOR RESTORING SENSITIVITY TO ANTIESTROGENIC COMPOUNDS IN BREAST TUMOUR CELLS
(FR) UTILISATION D'UN PEPTIDE DÉRIVÉ D'ER-ALPHA POUR RESTAURER LA SENSIBILITÉ AUX COMPOSÉS ANTI-ŒSTROGÉNIQUES DANS DES CELLULES DE TUMEUR DU SEIN
Abstract:
(EN) The present invention relates to the use of a peptide having a sequence with at least 90% identity with SEQ ID NO: 1 for the preparation of a medicament for restoring sensitivity to antiestrogenic compounds in antiestrogenic-resistant breast tumour cells. A conjugate of the peptide of SEQ ID NO: 1 with a peptide vehicle selected from the group consisting of TAT, Antennapedia (Antp) and Model Amphipathic Peptide (MAP) is also provided.
(FR) La présente invention concerne l'utilisation d'un peptide ayant une séquence présentant une identité d'au moins 90 % avec SEQ ID NO: 1 pour la préparation d'un médicament visant à restaurer la sensibilité aux composés anti-œstrogénique dans des cellules de tumeur du sein résistantes aux anti-œstrogéniques. L'invention concerne un conjugué du peptide de SEQ ID NO: 1 avec un véhicule peptidique choisi dans l'ensemble consistant en TAT, Antennapedia (Antp) et peptide amphipathique modèle (AMP).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)