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1. (WO2010072807) INHIBITORS OF CYSTAHIONINE BETA SYNTHASE FOR PREVENTING OR TREATING NEUROTOXIC OR COGNITIVE DISORDERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/072807 International Application No.: PCT/EP2009/067846
Publication Date: 01.07.2010 International Filing Date: 23.12.2009
IPC:
A61K 31/53 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
53
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
FONDATION JEROME LEJEUNE [FR/FR]; 31 rue Galande F-75005 Paris 5, FR (AllExceptUS)
BLEHAUT, Henri [FR/FR]; FR (UsOnly)
BELLAMY, François [FR/FR]; FR (UsOnly)
MATT, Christophe [FR/FR]; FR (UsOnly)
GIRAUD, Stéphane [FR/FR]; FR (UsOnly)
CHARRE, Damien [FR/FR]; FR (UsOnly)
Inventors:
BLEHAUT, Henri; FR
BELLAMY, François; FR
MATT, Christophe; FR
GIRAUD, Stéphane; FR
CHARRE, Damien; FR
Agent:
TETAZ, Franck; Cabinet Regimbeau 139 rue Vendôme F-69477 Lyon Cedex 06, FR
Priority Data:
61/140,30823.12.2008US
Title (EN) INHIBITORS OF CYSTAHIONINE BETA SYNTHASE FOR PREVENTING OR TREATING NEUROTOXIC OR COGNITIVE DISORDERS
(FR) INHIBITEURS DE CYSTATHIONINE BÊTA-SYNTHASE POUR RÉDUIRE LA SURPRODUCTION NEUROTOXIQUE DE SULFURE D'HYDROGÈNE ENDOGÈNE
Abstract:
(EN) The invention is directed to inhibitors of cystathionine beta synthase which, among other biochemical effects, allow reduction of the neurotoxic overproduction of endogenous hydrogen sulphide. These compounds and pharmaceutical compositions containing them are useful for the prevention and treatment of neurotoxic and cognitive disorders such as cognitive disorders in Down syndrome. The invention also relates to methods for preventing or treating neurotoxic and cognitive disorders including cognitive disorders in Down Syndrome.
(FR) L'invention concerne des inhibiteurs de cystathionine bêta-synthase qui, parmi d'autres effets biochimiques, permettent la réduction de la surproduction neurotoxique de sulfure d'hydrogène endogène. Ces composés et les compositions pharmaceutiques les contenant sont utiles pour la prévention et le traitement des troubles neurotoxiques et cognitifs, tels que les troubles cognitifs liés à la trisomie 21. L'invention concerne également des procédés permettant de prévenir ou de traiter des troubles neurotoxiques ou cognitifs, tels que les troubles cognitifs liés à la trisomie 21.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)