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1. (WO2010072752) FLUORESCENT PROBES HAVING A POLYMERIC BACKBONE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/072752 International Application No.: PCT/EP2009/067734
Publication Date: 01.07.2010 International Filing Date: 22.12.2009
Chapter 2 Demand Filed: 19.10.2010
IPC:
A61K 49/00 (2006.01) ,C12Q 1/34 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
34
involving hydrolase
Applicants:
GE HEALTHCARE AS [NO/NO]; Nycoveien 2 Postboks 4220 Nydalen N-0401 Oslo, NO (AllExceptUS)
TOLLESHAUG, Helge [NO/NO]; NO (UsOnly)
Inventors:
TOLLESHAUG, Helge; NO
Agent:
CANNING, Lewis, Reuben; GE Healthcare Limited Pollards Wood Nightingales Lane Chalfont St Giles Buckinghamshire HP8 4SP, GB
Priority Data:
0823315.722.12.2008GB
Title (EN) FLUORESCENT PROBES HAVING A POLYMERIC BACKBONE
(FR) SONDES FLUORESCENTES
Abstract:
(EN) The present invention relates to quenched fluorescent probes which arc activated by biochemical processes. The probes are designed such that intramolecular quenching occurs in the unactivated probe, but that the quencher moieties are cleaved from the probe under defined conditions rendering the probe fluorescent. Also disclosed are optical imaging agents suitable for in vivo imaging comprising the probes, as well as pharmaceutical compositions and kits, as well as in vivo imaging methods.
(FR) La présente invention concerne des sondes fluorescentes stoppées activées par des processus biochimiques. Les sondes sont conçues de sorte à ce que le stoppage intramoléculaire se produise dans la sonde inactivée, mais que les groupements stoppeurs soient clivés de la sonde dans des conditions définies qui permettent d'obtenir leur fluorescence. La présente invention concerne également des agents d'imagerie optique adaptés à l'imagerie in vivo incluant lesdites sondes, ainsi que des compositions pharmaceutiques et des kits, et des méthodes d'imagerie in vivo.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2389201JP2012513382US20110263975CN102325551