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1. (WO2010072597) DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/072597 International Application No.: PCT/EP2009/067026
Publication Date: 01.07.2010 International Filing Date: 14.12.2009
Chapter 2 Demand Filed: 15.09.2010
IPC:
C07D 401/12 (2006.01) ,C07D 413/12 (2006.01) ,A61K 31/44 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
Applicants:
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
BERGER, Jacob [US/US]; US (UsOnly)
CAROON, Joan Marie [US/US]; US (UsOnly)
KRAUSS, Nancy Elisabeth [US/US]; US (UsOnly)
LOPEZ-TAPIA, Francisco, Javier [US/US]; US (UsOnly)
WALKER, Keith, Adrian, Murray [US/US]; US (UsOnly)
ZHAO, Shu-Hai [US/US]; US (UsOnly)
Inventors:
BERGER, Jacob; US
CAROON, Joan Marie; US
KRAUSS, Nancy Elisabeth; US
LOPEZ-TAPIA, Francisco, Javier; US
WALKER, Keith, Adrian, Murray; US
ZHAO, Shu-Hai; US
Agent:
HEIROTH, Ulrike; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data:
61/203,48223.12.2008US
Title (EN) DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
(FR) DIHYDROPYRIDONE AMIDES EN TANT QUE MODULATEURS DE P2X7
Abstract:
(EN) Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
(FR) La présente invention concerne des composés de formule I ou leurs sels pharmaceutiquement acceptables, dans laquelle m, n, R1, R2, R3, R4, R5 et Ra sont tels que définis dans le présent document. La présente invention concerne en outre des procédés de fabrication des composés et d'utilisation des composés pour le traitement de maladies associées au récepteur purinergique P2X7.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AR074843IL213417MXMX/a/2011/006232SG172336EP2385939JP2012513433
CN102264723CA2745864MX2011006232KR1020110086768AU2009331659IN4420/CHENP/2011