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1. (WO2010072419) ENEMA PREPARATIONS AND THEIR USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/072419 International Application No.: PCT/EP2009/009293
Publication Date: 01.07.2010 International Filing Date: 23.12.2009
IPC:
A61K 9/00 (2006.01) ,A61K 47/10 (2006.01) ,A61K 47/12 (2006.01) ,A61K 47/14 (2006.01) ,A61K 47/18 (2006.01) ,A61K 47/20 (2006.01) ,A61K 47/34 (2006.01) ,A61K 47/38 (2006.01) ,A61K 41/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
12
Carboxylic acids; Salts or anhydrides thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
14
Esters of carboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
16
containing nitrogen
18
Amines; Quaternary ammonium compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
20
containing sulfur
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
38
Cellulose; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41
Medicinal preparations obtained by treating materials with wave energy or particle radiation
Applicants:
PHOTOCURE ASA [NO/NO]; Hoffsveien 4 N-0275 Oslo, NO (AllExceptUS)
GODAL, Aslak [NO/NO]; NO (UsOnly)
KLAVENESS, Jo [NO/NO]; NO (UsOnly)
Inventors:
GODAL, Aslak; NO
KLAVENESS, Jo; NO
Agent:
GOLDING, Louise; Dehns St. Bride's House 10 Salisbury Square London EC4Y 8JD, GB
Priority Data:
0823472.623.12.2008GB
Title (EN) ENEMA PREPARATIONS AND THEIR USE
(FR) PRÉPARATIONS DE LAVEMENT ET LEUR UTILISATION
Abstract:
(EN) This invention relates to improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions, and in particular to improved enema preparations for use in such methods, said enema preparations comprising a photosensitiser which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester. Such preparations may further comprise one or more viscosity enhancing agents, mucoadhesive or mucolytic agents, penetration enhancers or chelating agents. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing cancer and non-cancerous conditions in the colon and/or rectum.
(FR) La présente invention concerne des procédés améliorés de traitement et de diagnostic photodynamique du cancer et d'affections non cancéreuses, et en particulier des préparations de lavement améliorées pour utilisation dans de tels procédés, lesdites préparations de lavement comprenant un photosensibilisateur qui est l'acide 5-aminolévulinique (5-ALA) ou un précurseur ou dérivé de celui-ci, par exemple un ester de 5-ALA. De telles préparations peuvent comprendre en outre un ou plusieurs agents d'amélioration de la viscosité, des agents mucoadhésifs ou mucolytiques, des agents de pénétration ou des agents chélateurs. Les procédés et préparations présentement décrits sont particulièrement adaptés pour utilisation dans des procédés photodynamiques de traitement et/ou de diagnostic du cancer et d'affections non cancéreuses dans le côlon et/ou le rectum.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL213598EP2370056MXMX/a/2011/006841SG172365JP2012513429US20110293528
CN102264347RU2011127680CA2748155MX2011006841KR1020110104523NZ593657
AU2009331842IN4570/DELNP/2011