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1. (WO2010072418) A PROCESS FOR PURIFYING A POLYMER MIXTURE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/072418 International Application No.: PCT/EP2009/009272
Publication Date: 01.07.2010 International Filing Date: 24.12.2009
IPC:
C07K 14/00 (2006.01) ,C07K 1/34 (2006.01) ,C08G 69/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
34
by filtration, ultrafiltration or reverse osmosis
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
69
Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
02
Polyamides derived from amino carboxylic acids or from polyamines and polycarboxylic acids
08
derived from amino carboxylic acids
10
Alpha-amino-carboxylic acids
Applicants:
SYNTHON BV [NL/NL]; Microweg 22 NL-6545 CM Nijmegen, NL (AllExceptUS)
LUTEN, Jordy [NL/NL]; NL (UsOnly)
Inventors:
LUTEN, Jordy; NL
Priority Data:
61/140,75124.12.2008US
Title (EN) A PROCESS FOR PURIFYING A POLYMER MIXTURE
(FR) PROCÉDÉ POUR LA PURIFICATION D'UN MÉLANGE DE POLYMÈRES
Abstract:
(EN) A process for purifying copolymer peptides such as COP-I polypeptides by ultrafiltration can be improved by treating the polypeptide solution with an acid before or during the early stages of the ultrafiltration. Adding the acid and/or forming acid addition salts of the polypeptide before ultrafiltration is conducted permits for faster ultrafiltration. Likewise, adding the acid in the ultrafiltration process but before polypeptide precipitation or clogging occurs can also improve the efficiency / convenience of the ultrafiltration step.
(FR) L'invention porte sur un procédé pour la purification de peptides copolymères tels que des polypeptides COP-I par ultrafiltration qui peut être amélioré par traitement de la solution de polypeptide avec un acide avant ou pendant les premières phases de l'ultrafiltration. L'ajout de l'acide et/ou la formation de sels d'addition d'acide du polypeptide avant la mise en œuvre de l'ultrafiltration permet une ultrafiltration plus rapide. De même, l'ajout de l'acide dans le procédé d'ultrafiltration mais avant la survenue de la précipitation du polypeptide ou du bouchage par le polypeptide permet également d'améliorer l'efficacité/la commodité de l'étape d'ultrafiltration.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NZ593576AR074881EP2382233EA201170881EP2796463MX2011006677
CO6382160KR1020110112366AU2009331841ES2584529BRPI0922337PT2382233