Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2010072409) PROCESS FOR PREPARATION OF IVABRADINE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/072409 International Application No.: PCT/EP2009/009234
Publication Date: 01.07.2010 International Filing Date: 22.12.2009
IPC:
C07C 209/88 (2006.01) ,C07C 59/50 (2006.01) ,C07D 223/16 (2006.01) ,C07C 213/10 (2006.01) ,C07C 217/58 (2006.01) ,C07C 217/74 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
209
Preparation of compounds containing amino groups bound to a carbon skeleton
82
Purification; Separation; Stabilisation; Use of additives
86
Separation
88
Separation of optical isomers
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40
Unsaturated compounds
42
containing hydroxy or O-metal groups
48
containing six-membered aromatic rings
50
Mandelic acid
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
223
Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
14
condensed with carbocyclic rings or ring systems
16
Benzazepines; Hydrogenated benzazepines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
213
Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
10
Separation; Purification; Stabilisation; Use of additives
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
217
Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
54
having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
56
with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
58
with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
217
Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
54
having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
74
with rings other than six-membered aromatic rings being part of the carbon skeleton
Applicants:
KRKA, D. D., NOVO MESTO [SI/SI]; Smarjeska cesta 6 8501 Novo Mesto, SI (AllExceptUS)
BOSE, Prosenjit [IN/IN]; IN (UsOnly)
SIRIPALLI, Udaya Bhaskara Rao [IN/IN]; IN (UsOnly)
KANDADAI, Appan Srinivas [IN/IN]; IN (UsOnly)
Inventors:
BOSE, Prosenjit; IN
SIRIPALLI, Udaya Bhaskara Rao; IN
KANDADAI, Appan Srinivas; IN
Agent:
WESTENDORP | SOMMER; Uhlandstrasse 2 80336 München, DE
Priority Data:
P-200800320 22.12.2008SI
Title (EN) PROCESS FOR PREPARATION OF IVABRADINE
(FR) PROCÉDÉ POUR LA PRÉPARATION D'IVABRADINE
Abstract:
(EN) The present invention describes a new process for optical resolution of [N-[[3,4- dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]-N-methylamine] which is an intermediate in the preparation of ivabradine.
(FR) La présente invention porte sur un nouveau procédé pour la résolution optique de la [N-[[3,4-diméthoxybicyclo[4.2.0]octa-1,3,5-trién-7-yl]méthyl]-N-méthylamine] qui est un intermédiaire dans la préparation de l'ivabradine.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2367782CN102264689