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1. (WO2010072381) IMMUNOGLOBULIN PURIFICATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/072381 International Application No.: PCT/EP2009/009157
Publication Date: 01.07.2010 International Filing Date: 18.12.2009
IPC:
A61K 39/395 (2006.01) ,C07K 16/06 (2006.01) ,C07K 1/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
06
from serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
16
by chromatography
18
Ion-exchange chromatography
Applicants:
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
POMPIATI, Marc [DE/DE]; DE (UsOnly)
SCHAUBMAR, Andreas [DE/DE]; DE (UsOnly)
Inventors:
POMPIATI, Marc; DE
SCHAUBMAR, Andreas; DE
Agent:
BURGER, Alexander; Roche Diagnostics GmbH Patentabteilung (TR-E) Postfach 11 52 82372 Penzberg, DE
Priority Data:
08022236.722.12.2008EP
Title (EN) IMMUNOGLOBULIN PURIFICATION
(FR) PURIFICATION D'IMMUNOGLOBULINE
Abstract:
(EN) The current invention reports a method for purifying an immunoglobulin, wherein the method comprises applying an aqueous, buffered solution comprising an immunoglobulin in monomeric, in aggregated, and in fragmented form to an anion exchange chromatography material under conditions whereby the immunoglobulin in monomeric form does not bind to the anion exchange material, and recovering the immunoglobulin in monomeric form in the flow-through from the anion exchange chromatography material, whereby the buffered aqueous solution has a pH value of from 8.0 to 8.5. In one embodiment the anion exchange chromatography material is a membrane anion exchange chromatography material.
(FR) La présente invention porte sur un procédé pour purifier une immunoglobuline, le procédé comprenant l'application d'une solution tamponnée, aqueuse, comprenant une immunoglobuline sous forme monomère, agrégée et fragmentée sur un matériau de chromatographie échangeuse d'anions dans des conditions où l'immunoglobuline sous forme monomère ne se lie pas au matériau d'échange d'anions, et la récupération de l'immunoglobuline sous forme monomère dans l'écoulement traversant à partir du matériau de chromatographie échangeuse d'anions, la solution aqueuse tamponnée ayant une valeur de pH de 8,0 à 8,5. Dans un mode de réalisation, le matériau de chromatographie échangeuse d'anions est un matériau de chromatographie échangeuse d'anions membranaire.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL212646MXMX/a/2011/006654EP2379108JP2012513425US20110257370CN102264392
CA2745707ES2488542MX2011006654KR1020110086184BRPI0923541AU2009331897
IN4355/CHENP/2011US20180162930