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1. (WO2010072365) SINGLE RECOMBINATION SYSTEM AND METHODS OF USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/072365 International Application No.: PCT/EP2009/009028
Publication Date: 01.07.2010 International Filing Date: 16.12.2009
IPC:
C12N 15/863 (2006.01) ,A61K 39/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
863
Poxviral vectors, e.g. vaccinia virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
EMERGENT PRODUCT DEVELOPMENT GERMANY GmbH [DE/DE]; Walter-Gropius-Strasse 17 80807 Munich, DE (AllExceptUS)
LEYRER, Sonja [DE/DE]; DE (UsOnly)
MAYER, Katja [DE/DE]; DE (UsOnly)
Inventors:
LEYRER, Sonja; DE
MAYER, Katja; DE
Agent:
GRUND, Martin; Intellectual Property Group Postfach 44 05 16 80754 Munich, DE
Priority Data:
08022296.122.12.2008EP
61/139, 99122.12.2008US
Title (EN) SINGLE RECOMBINATION SYSTEM AND METHODS OF USE
(FR) SYSTÈME DE RECOMBINAISON UNIQUE ET SES MÉTHODES D'UTILISATION
Abstract:
(EN) The present invention is directed to a modified poxvirus vector that allows for the generation of recombinant poxviruses by a single recombination event. A modified poxvirus vector comprising at least one reporter gene located between two flanking sequences for homologous recombination is disclosed. Furthermore, a host cell comprising said vector and a method for the generation of recombinant poxviruses using said vector are provided.
(FR) La présente invention concerne un vecteur de poxvirus modifié permettant la génération de poxvirus recombinants par le biais d'un événement de recombinaison unique. La présente invention concerne également un vecteur de poxvirus modifié comprenant au moins un gène marqueur encadré par deux séquences pour recombinaison homologue. La présente invention concerne en outre une cellule hôte comprenant ledit vecteur et une méthode de génération de poxvirus recombinants à l'aide dudit vecteur.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2367945SG172310JP2012513208US20120028336CN102264909CA2746009
EA201170854KR1020110126586NZ593385AU2009331881IN5214/DELNP/2011