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1. WO2010072352 - 1, 2, 4 -OXADIAZOLE DERIVATIVES AND THEIR THERAPEUTIC USE

Publication Number WO/2010/072352
Publication Date 01.07.2010
International Application No. PCT/EP2009/008968
International Filing Date 15.12.2009
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245
Oxadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
C07D 413/04 (2006.01)
C07D 413/14 (2006.01)
C07D 471/04 (2006.01)
A61K 31/4245 (2006.01)
A61P 35/00 (2006.01)
A61P 29/00 (2006.01)
CPC
C07D 413/04
C07D 413/14
C07D 471/04
Applicants
  • ALMIRALL S.A. [ES/ES]; Ronda del General Mitre, 151 E-08022 Barcelona, ES (AllExceptUS)
  • GIULIO MATASSA, Victor [GB/ES]; ES (UsOnly)
  • AGUILAR IZQUIERDO, Nuria [ES/ES]; ES (UsOnly)
  • MIR CEPEDA, Marta [ES/ES]; ES (UsOnly)
  • CARRASCAL RIERA, Marta [ES/ES]; ES (UsOnly)
  • FONQUERNA POU, Silvia [ES/ES]; ES (UsOnly)
  • CARDUS FIGUERAS, Aranzazu [ES/ES]; ES (UsOnly)
  • CASTRO PALOMINO LARIA, Julio, Cesar [ES/ES]; ES (UsOnly)
  • ERRA SOLA, Montserrat [ES/ES]; ES (UsOnly)
Inventors
  • GIULIO MATASSA, Victor; ES
  • AGUILAR IZQUIERDO, Nuria; ES
  • MIR CEPEDA, Marta; ES
  • CARRASCAL RIERA, Marta; ES
  • FONQUERNA POU, Silvia; ES
  • CARDUS FIGUERAS, Aranzazu; ES
  • CASTRO PALOMINO LARIA, Julio, Cesar; ES
  • ERRA SOLA, Montserrat; ES
Agents
  • SRINIVASAN, Ravi, Chandran; J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5JJ, GB
Priority Data
08382090.226.12.2008EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 1, 2, 4 -OXADIAZOLE DERIVATIVES AND THEIR THERAPEUTIC USE
(FR) DÉRIVÉS DE 1,2,4-OXADIAZOLE ET LEUR UTILISATION THÉRAPEUTIQUE
Abstract
(EN)
New derivatives of general formula (I), or pharmaceutically acceptable salts or N- oxides thereof wherein,either (i) A is selected from the group consisting of -N-, -O- and -S-; B and C are independently selected from the group consisting of -N- and -O-, with the proviso that two of A, B and C are nitrogen atoms, or (ii) two of A, B and C are -N- and one of A, B and C is -NH-; G1 is selected from the group consisting of -CH2-, -NH- and -O-; G2 is selected from the group consisting of -NR4- and -O-; R1 represents: > a 8 to 10 membered bicyclic N-containing heteroaryl group optionally substituted with a C1-4 carboxyalkyl group or a C1-4 aminoalkyl group, > a pyridyl group optionally substituted with one or more substituents selected from hydroxy groups, C1-4 alkyl groups, C1-4 carboxyalkyl groups, C1-4 haloalkyl groups, C1-4 alkoxy groups, amino groups, C1-4 aminoalkyl groups and C1-4 aminoalkoxy groups, > a pyridone group substituted with one or more C1-4 alkyl groups; C1-4 haloalkyl groups or C1-4 aminoalkyl groups, or > a group of formula:
(FR)
La présente invention concerne de nouveaux dérivés de formule générale (I), les sels pharmaceutiquement acceptables et les N-oxydes de ceux-ci.
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